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Tbio
SAT2
Diamine acetyltransferase 2

Protein Summary
Description
Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine > spermidine = spermine >> N(1)acetylspermine = putrescine.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269298
  • ENSP00000269298
  • ENSG00000141504

Symbol
  • SSAT2
  • SSAT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.72
kinase perturbation
0.71
histone modification site profile
0.66
virus perturbation
0.64
cell type or tissue
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.72   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 123   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.72   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (23)
PANK2
Tbio
Family:  Kinase
Novelty:  0.00465551
p_int:  0.999999647
p_ni:  1.03e-7
p_wrong:  2.5e-7
Score:  0.685
Data Source:  BioPlex,STRINGDB
NRBP1
Tbio
Family:  Kinase
Novelty:  0.05902656
p_int:  0.911778683
p_ni:  0.088216835
p_wrong:  0.000004482
Data Source:  BioPlex
PAOX
Tchem
Family:  Enzyme
Novelty:  0.00905719
Score:  0.979
Data Source:  STRINGDB
SRM
Tchem
Family:  Enzyme
Novelty:  0.01583759
Score:  0.938
Data Source:  STRINGDB
SMOX
Tbio
Family:  Enzyme
Novelty:  0.0071711
Score:  0.935
Data Source:  STRINGDB
ODC1
Tclin
Family:  Enzyme
Novelty:  0.00037968
Score:  0.933
Data Source:  STRINGDB
HIF1A
Tchem
Family:  TF
Novelty:  0.00011503
Score:  0.908
Data Source:  STRINGDB
AGMAT
Tbio
Family:  Enzyme
Novelty:  0.03970349
Score:  0.907
Data Source:  STRINGDB
AOC1
Tchem
Family:  Enzyme
Novelty:  0.00146464
Score:  0.903
Data Source:  STRINGDB
MAOB
Tclin
Family:  Enzyme
Novelty:  0.00030366
Score:  0.903
Data Source:  STRINGDB
Pathways (20)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Arginine and proline metabolism
KEGG
Ferroptosis
KEGG
Metabolic pathways
Name
Explore in Pharos
Explore in Source
Arginine and proline metabolism
Ferroptosis
Metabolic pathways
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (63)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
10
30
40
100
sex hormone-binding globulin measurement
8
8
21
99.7
serum non-albumin protein measurement
3
9
11
99.2
blood protein measurement
2
5
5
96.9
hormone measurement
2
3
1
57
94.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
40
100
sex hormone-binding globulin measurement
21
99.7
serum non-albumin protein measurement
11
99.2
blood protein measurement
5
96.9
hormone measurement
1
57
94.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
spermidine/spermine N1-acetyltransferase family member 2
716044
Mouse
MGI:1916465
69215
Rat
RGD:1307869
360547
Dog
spermidine/spermine N1-acetyltransferase family member 2
VGNC:45874
100856136
Horse
spermidine/spermine N1-acetyltransferase family member 2
VGNC:22699
100073008
Species
Name
OMA
EggNOG
Inparanoid
Macaque
spermidine/spermine N1-acetyltransferase family member 2
Mouse
Rat
Dog
spermidine/spermine N1-acetyltransferase family member 2
Horse
spermidine/spermine N1-acetyltransferase family member 2
Publication Statistics
PubMed Score 9.72
PubMed score by year
PubTator Score 92.49
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title