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Tbio
SART1
U4/U6.U5 tri-snRNP-associated protein 1

Protein Summary
Description
Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recru ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312397
  • ENSP00000310448
  • ENSG00000175467

Symbol
  • HAF
  • Ara1
  • HOMS1
  • Snu66
  • SART1259
  • SNRNP110
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
hub protein
0.79
histone modification site profile
0.72
biological process
0.67
tissue
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.24   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.24   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (281)
PRPF3
Tbio
Novelty:  0.01600014
p_int:  0.991967865
p_ni:  0.008032135
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRPGP15
Tdark
p_int:  0.990567342
p_ni:  0.009432658
Data Source:  BioPlex
PRPF4
Tchem
Novelty:  0.08229072
p_int:  0.983749469
p_ni:  0.016250531
Score:  0.998
Data Source:  BioPlex,STRINGDB
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.976798209
p_ni:  0.023201791
Score:  0.997
Data Source:  BioPlex,STRINGDB
RBM42
Tdark
Novelty:  0.37655036
p_int:  0.953975825
p_ni:  0.046024175
Score:  0.817
Data Source:  BioPlex,STRINGDB
DDX23
Tbio
Family:  Enzyme
Novelty:  0.03592096
p_int:  0.91575389
p_ni:  0.08424611
Score:  0.996
Data Source:  BioPlex,STRINGDB
LSM5
Tbio
Novelty:  0.12669584
p_int:  0.904386777
p_ni:  0.095613223
Score:  0.999
Data Source:  BioPlex,STRINGDB
LSM7
Tbio
Novelty:  0.09112723
p_int:  0.809850304
p_ni:  0.190149696
Score:  0.998
Data Source:  BioPlex,STRINGDB
LSM3
Tbio
Novelty:  0.05044984
p_int:  0.800902791
p_ni:  0.199097209
Score:  0.996
Data Source:  BioPlex,STRINGDB
SNU13
Tbio
Novelty:  0.01613497
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
2
3
93.7
eosinophil percentage of leukocytes
2
2
2
91.6
uric acid measurement
2
2
2
89.6
body height
2
2
2
75.6
sum of eosinophil and basophil counts
1
1
1
74.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
93.7
eosinophil percentage of leukocytes
2
91.6
uric acid measurement
2
89.6
body height
2
75.6
sum of eosinophil and basophil counts
1
74.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SART1, U4/U6.U5 tri-snRNP-associated protein 1
VGNC:1009
100615300
Macaque
SART1, U4/U6.U5 tri-snRNP-associated protein 1
721873
Mouse
MGI:1309453
20227
Rat
RGD:61930
29678
Dog
SART1, U4/U6.U5 tri-snRNP-associated protein 1
VGNC:45870
483721
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SART1, U4/U6.U5 tri-snRNP-associated protein 1
Macaque
SART1, U4/U6.U5 tri-snRNP-associated protein 1
Mouse
Rat
Dog
SART1, U4/U6.U5 tri-snRNP-associated protein 1
Publication Statistics
PubMed Score 125.24
PubMed score by year
PubTator Score 36.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title