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Tbio
SARS2
Serine--tRNA ligase, mitochondrial

Protein Summary
Description
Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis of selenocysteinyl-tRNA(sec) in mitochondria. The enzyme contains an N-terminal tRNA binding domain and a core catalytic domain. It functions in a homodimeric form, which is stabilized by tRNA binding. This gene is regulated by a bidirectional promoter that also controls the expression of mitochondrial ribosomal protein S12. Both genes are within the critical interval for the autosomal dominant deafness locus DFNA4 and might be linked to this disease. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221431
  • ENSP00000221431
  • ENSG00000104835
  • ENST00000600042
  • ENSP00000472847
  • ENST00000634687
  • ENSP00000489539
  • ENSG00000283104
  • ENST00000635245
  • ENSP00000489453

Symbol
  • SARSM
  • SYS
  • SARS
  • SERS
  • SARSM
  • SerRS
  • SerRSmt
  • mtSerRS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.94
molecular function
0.93
protein domain
0.73
transcription factor binding site profile
0.72
tissue
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 351.52   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 351.52   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (105)
KCMF1
Tbio
Family:  Enzyme
Novelty:  0.05485534
p_int:  0.991974719
p_ni:  0.008025281
Score:  0.234
Data Source:  BioPlex,STRINGDB
FBXO17
Tbio
Novelty:  0.1320754
p_int:  0.966440647
p_ni:  0.033559353
Score:  0.33
Data Source:  BioPlex,STRINGDB
BPNT1
Tbio
Family:  Enzyme
Novelty:  0.1114547
p_int:  0.81644932
p_ni:  0.18355068
Score:  0.207
Data Source:  BioPlex,STRINGDB
PSTK
Tbio
Family:  Kinase
Novelty:  0.0280647
Score:  0.991
Data Source:  STRINGDB
YARS
Tchem
Family:  Enzyme
Novelty:  0.00302115
Score:  0.968
Data Source:  STRINGDB
TARS
Tchem
Family:  Enzyme
Novelty:  0.00795387
Score:  0.904
Data Source:  STRINGDB
YARS2
Tbio
Family:  Enzyme
Novelty:  0.00522139
Score:  0.904
Data Source:  STRINGDB
EPRS
Tchem
Family:  Enzyme
Novelty:  0.00084896
Score:  0.896
Data Source:  STRINGDB
LARS2
Tbio
Family:  Enzyme
Novelty:  0.00543895
Score:  0.894
Data Source:  STRINGDB
GARS
Tchem
Family:  Enzyme
Novelty:  0.00190498
Score:  0.893
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (24)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial tRNA aminoacylation
Reactome
Translation
Reactome
tRNA Aminoacylation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial tRNA aminoacylation
Translation
tRNA Aminoacylation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
SIR2-like protein 2 measurement
1
1
1
82.5
SIR2-like protein 2 measurement
1
1
1
82.5
blood protein measurement
1
1
1
73.3
blood protein measurement
1
1
1
73.3
diastolic blood pressure
1
1
1
49.7
Items per page:
1 – 5 of 8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
SIR2-like protein 2 measurement
1
82.5
SIR2-like protein 2 measurement
1
82.5
blood protein measurement
1
73.3
blood protein measurement
1
73.3
diastolic blood pressure
1
49.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1919234
71984
Rat
RGD:1309456
292759
Cow
seryl-tRNA synthetase 2, mitochondrial
282060
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
seryl-tRNA synthetase 2, mitochondrial
Publication Statistics
PubMed Score 351.52
PubMed score by year
PubTator Score 1106.51
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title