Tbio SARS Serine--tRNA ligase, cytoplasmic

Protein Summary

Description

Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser) (PubMed:22353712, PubMed:24095058, PubMed:9431993, PubMed:26433229, PubMed:28236339). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (PubMed:9431993, PubMed:26433229, PubMed:28236339). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC (PubMed:24940000). Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA (PubMed:19423848, PubMed:19423847, PubMed:24940000). This gene belongs to the class II amino-acyl tRNA family. The encoded enzyme catalyzes the transfer of L-serine to tRNA (Ser) and is related to bacterial and yeast counterparts. Multiple alternatively spliced transcript variants have been described but the biological validity of all variants is unknown. [provided by RefSeq, Jul 2010]

Uniprot Accession IDs

• P49591
• B2R6Y9
• Q5T5C8
• Q9NSE3

Gene Name

• SARS

Ensembl ID

• ENST00000234677
• ENSP00000234677
• ENSG00000031698

Symbol

• SERS
• SERS
• SERRS
• NEDMAS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
transcription factor perturbation	0.99
virus perturbation	0.98
kinase perturbation	0.93
molecular function	0.91

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Serine--trna Ligase, Cytoplasmic

Protein / Ligase / Aminoacyl-trna Synthetase / Serine--trna Ligase, Cytoplasmic

DTO Classes

Protein / Enzyme / Ligase / Aminoacyl-trna Synthetase / Serine--trna Ligase, Cytoplasmic

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.13   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 214   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.13   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0