You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SARNP
SAP domain-containing ribonucleoprotein

Protein Summary
Description
Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. This ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336133
  • ENSP00000337632
  • ENSG00000205323
  • ENST00000546604
  • ENSP00000449409

Symbol
  • HCC1
  • HCC1
  • THO1
  • CIP29
  • HSPC316
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
disease perturbation
0.74
transcription factor
0.72
transcription factor binding site profile
0.72
kinase perturbation
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.57   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.57   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (188)
ZC3H11A
Tbio
Novelty:  0.49683634
p_int:  0.999982022
p_ni:  0.000017978
Score:  0.955
Data Source:  BioPlex,STRINGDB
DNAJC14
Tbio
Novelty:  0.05383843
p_int:  0.999943013
p_ni:  0.000056986
Score:  0.712
Data Source:  BioPlex,STRINGDB
CCDC9
Tdark
Novelty:  0.73149492
p_int:  0.999776903
p_ni:  0.000223093
p_wrong:  4e-9
Score:  0.203
Data Source:  BioPlex,STRINGDB
ZC3H14
Tbio
Novelty:  0.07532778
p_int:  0.999543448
p_ni:  0.000456552
Score:  0.229
Data Source:  BioPlex,STRINGDB
FYTTD1
Tbio
Novelty:  0.04600073
p_int:  0.999111207
p_ni:  0.000888793
Score:  0.979
Data Source:  BioPlex,STRINGDB
KBTBD7
Tdark
Novelty:  0.4947466
p_int:  0.991889061
p_ni:  0.008110939
Data Source:  BioPlex
ACIN1
Tbio
Novelty:  0.01675479
p_int:  0.985529391
p_ni:  0.014470609
Score:  0.364
Data Source:  BioPlex,STRINGDB
CHTOP
Tbio
Novelty:  0.04170391
p_int:  0.98183031
p_ni:  0.01816969
Score:  0.989
Data Source:  BioPlex,STRINGDB
NCBP3
Tbio
Novelty:  0.07581882
p_int:  0.973008211
p_ni:  0.026991144
p_wrong:  6.45e-7
Score:  0.76
Data Source:  BioPlex,STRINGDB
RNPS1
Tbio
Novelty:  0.03203224
p_int:  0.939502037
p_ni:  0.060497963
Score:  0.925
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase II Transcription Termination
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Transcription
RNA Polymerase II Transcription Termination
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
3
3
3
13.8
96.4
Myopia
3
2
0
1.3
93
age at onset
1
1
0
13.8
83.1
Abnormality of refraction
1
1
1
53.3
atrophic macular degeneration
1
1
0
1.2
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
3
13.8
96.4
Myopia
0
1.3
93
age at onset
0
13.8
83.1
Abnormality of refraction
1
53.3
atrophic macular degeneration
0
1.2
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SAP domain containing ribonucleoprotein
VGNC:5577
467031
Macaque
SAP domain containing ribonucleoprotein
709932
Mouse
MGI:1913368
66118
Mouse
MGI:3646907
625193
Rat
RGD:1305692
362819
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SAP domain containing ribonucleoprotein
Macaque
SAP domain containing ribonucleoprotein
Mouse
Mouse
Rat
Publication Statistics
PubMed Score 98.57
PubMed score by year
PubTator Score 39.62
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title