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Tchem
SARM1
Sterile alpha and TIR motif-containing protein 1

Protein Summary
Description
Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000585482
  • ENSP00000468032
  • ENSG00000004139

Symbol
  • KIAA0524
  • SAMD2
  • SARM
  • SARM
  • SAMD2
  • MyD88-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
protein domain
0.85
cellular component
0.73
microRNA
0.65
cell type or tissue
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 226.5   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 186   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 226.5   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (80)
GHITM
Tbio
Novelty:  0.00360652
p_int:  0.99999997
p_ni:  3e-8
Score:  0.212
Data Source:  BioPlex,STRINGDB
ZG16B
Tbio
Novelty:  0.08792924
p_int:  0.999999066
p_ni:  9.34e-7
Data Source:  BioPlex
CAV3
Tbio
Novelty:  0.00190092
p_int:  0.999993235
p_ni:  0.000006765
Data Source:  BioPlex
POC1B
Tbio
Novelty:  0.09023863
p_int:  0.99995905
p_ni:  0.000040885
p_wrong:  6.5e-8
Score:  0.179
Data Source:  BioPlex,STRINGDB
CARNMT1
Tbio
Family:  Enzyme
Novelty:  0.28121779
p_int:  0.999717727
p_ni:  0.000282268
p_wrong:  4e-9
Score:  0.231
Data Source:  BioPlex,STRINGDB
C1orf87
Tbio
Novelty:  0.03162594
p_int:  0.999685744
p_ni:  0.000314256
Score:  0.163
Data Source:  BioPlex,STRINGDB
RHOT2
Tbio
Family:  Enzyme
Novelty:  0.01712732
p_int:  0.996473913
p_ni:  0.003525779
p_wrong:  3.08e-7
Score:  0.209
Data Source:  BioPlex,STRINGDB
SEMA4C
Tbio
Novelty:  0.01237067
p_int:  0.995567235
p_ni:  0.004355617
p_wrong:  0.000077148
Data Source:  BioPlex
CHRM4
Tclin
Family:  GPCR
Novelty:  0.00759817
p_int:  0.976280036
p_ni:  0.022372534
p_wrong:  0.00134743
Data Source:  BioPlex
RS1
Tbio
Novelty:  0.00652544
Score:  0.928
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon (R-HSA-936964)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Reactome
IKK complex recruitment mediated by RIP1
Reactome
Immune System
Reactome
Innate Immune System
Reactome
MyD88-independent TLR4 cascade
Name
Explore in Pharos
Explore in Source
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
IKK complex recruitment mediated by RIP1
Immune System
Innate Immune System
MyD88-independent TLR4 cascade
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
8
4
9
92.8
osteoprotegerin measurement
2
1
2
86.6
interleukin-27 measurement
1
1
1
84.6
apolipoprotein B measurement
2
3
3
83
apolipoprotein A 1 measurement
2
2
2
81.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
9
92.8
osteoprotegerin measurement
2
86.6
interleukin-27 measurement
1
84.6
apolipoprotein B measurement
3
83
apolipoprotein A 1 measurement
2
81.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2136419
237868
Rat
RGD:1310078
287545
Dog
sterile alpha and TIR motif containing 1
VGNC:45868
491165
Horse
sterile alpha and TIR motif containing 1
VGNC:22692
100059075
Cow
sterile alpha and TIR motif containing 1
VGNC:34290
536256
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
sterile alpha and TIR motif containing 1
Horse
sterile alpha and TIR motif containing 1
Cow
sterile alpha and TIR motif containing 1
Publication Statistics
PubMed Score 226.50
PubMed score by year
PubTator Score 89.31
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title