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Tbio
SARDH
Sarcosine dehydrogenase, mitochondrial

Protein Summary
Description
This gene encodes an enzyme localized to the mitochondrial matrix which catalyzes the oxidative demethylation of sarcosine. This enzyme is distinct from another mitochondrial matrix enzyme, dimethylglycine dehydrogenase, which catalyzes a reaction resulting in the formation of sarcosine. Mutations in this gene are associated with sarcosinemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371872
  • ENSP00000360938
  • ENSG00000123453
  • ENST00000439388
  • ENSP00000403084

Symbol
  • DMGDHL1
  • SAR
  • SDH
  • SARD
  • BPR-2
  • DMGDHL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
protein domain
0.73
disease perturbation
0.68
tissue sample
0.65
gene perturbation
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.01   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 52   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.01   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 52   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
SHMT2
Tchem
Family:  Enzyme
Novelty:  0.00234505
Score:  0.979
Data Source:  STRINGDB
GLDC
Tbio
Family:  Enzyme
Novelty:  0.00900467
Score:  0.978
Data Source:  STRINGDB
SHMT1
Tbio
Family:  Enzyme
Novelty:  0.00200739
Score:  0.977
Data Source:  STRINGDB
PIPOX
Tbio
Family:  Enzyme
Novelty:  0.04107707
Score:  0.96
Data Source:  STRINGDB
DAO
Tchem
Family:  Enzyme
Novelty:  0.00414923
Score:  0.944
Data Source:  STRINGDB
DMGDH
Tbio
Family:  Enzyme
Novelty:  0.03936436
Score:  0.925
Data Source:  STRINGDB
GATM
Tbio
Family:  Enzyme
Novelty:  0.00340356
Score:  0.924
Data Source:  STRINGDB
AGXT
Tbio
Family:  Enzyme
Novelty:  0.00267512
Score:  0.919
Data Source:  STRINGDB
ALAS1
Tclin
Family:  Enzyme
Novelty:  0.00965779
Score:  0.918
Data Source:  STRINGDB
AGXT2
Tbio
Family:  Enzyme
Novelty:  0.02018289
Score:  0.913
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (18)
Choline catabolism (R-HSA-6798163)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Choline catabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Choline catabolism
Metabolism
Metabolism of amino acids and derivatives
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking cessation
3
6
8
99.2
cigarettes per day measurement
3
5
6
98.3
diastolic blood pressure
3
2
3
91.8
smoking behaviour measurement
1
1
1
90.8
blood protein measurement
1
1
1
84.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking cessation
8
99.2
cigarettes per day measurement
6
98.3
diastolic blood pressure
3
91.8
smoking behaviour measurement
1
90.8
blood protein measurement
1
84.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sarcosine dehydrogenase
VGNC:4856
464828
Macaque
sarcosine dehydrogenase
713289
Mouse
MGI:2183102
192166
Rat
RGD:621125
114123
Dog
sarcosine dehydrogenase
VGNC:45867
491277
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sarcosine dehydrogenase
Macaque
sarcosine dehydrogenase
Mouse
Rat
Dog
sarcosine dehydrogenase
Publication Statistics
PubMed Score 43.01
PubMed score by year
PubTator Score 1080.07
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title