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Tbio
SAPCD2
Suppressor APC domain-containing protein 2

Protein Summary
Description
Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions (By similarity). Negatively regulates the mitotic apical cortex localization of GPSM2 (PubMed:26766442). Involved also in positive regulation of cell proliferation and tumor cell growth (PubMed:23576022, PubMed:23704824).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000409687
  • ENSP00000386348
  • ENSG00000186193

Symbol
  • C9orf140
  • p42.3
  • C9orf140
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.68
cell type or tissue
0.58
histone modification site profile
0.57
cellular component
0.54
cell line
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.66   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 51   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.66   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (25)
SPERT
Tbio
Novelty:  0.12255061
p_int:  0.999999845
p_ni:  1.54e-7
p_wrong:  1e-9
Score:  0.239
Data Source:  BioPlex,STRINGDB
RALBP1
Tbio
Novelty:  0.01525176
p_int:  0.999999366
p_ni:  6.34e-7
Data Source:  BioPlex
GPSM1
Tbio
Novelty:  0.03510582
p_int:  0.999999351
p_ni:  6.49e-7
Score:  0.28
Data Source:  BioPlex,STRINGDB
IFT20
Tbio
Novelty:  0.03005088
p_int:  0.999995783
p_ni:  0.000004217
Data Source:  BioPlex
PLIN5
Tbio
Novelty:  0.01265845
p_int:  0.999941801
p_ni:  0.000058188
p_wrong:  1e-8
Score:  0.52
Data Source:  BioPlex,STRINGDB
MID1IP1
Tbio
Novelty:  0.11443752
p_int:  0.999901502
p_ni:  0.000098493
p_wrong:  5e-9
Data Source:  BioPlex
CHGA
Tbio
Novelty:  0.00033267
p_int:  0.999766392
p_ni:  0.00023359
p_wrong:  1.8e-8
Score:  0.269
Data Source:  BioPlex,STRINGDB
DEPDC1
Tbio
Novelty:  0.04255829
p_int:  0.985452691
p_ni:  0.002627382
p_wrong:  0.011919927
Score:  0.347
Data Source:  BioPlex,STRINGDB
ARHGEF39
Tdark
Novelty:  0.30447134
Score:  0.571
Data Source:  STRINGDB
CDC20
Tbio
Novelty:  0.00197887
Score:  0.541
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
3
4
91.5
monocyte percentage of leukocytes
2
2
2
88
leukocyte count
2
2
3
70.2
central corneal thickness
3
2
0
2.9
69.8
lymphocyte percentage of leukocytes
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
4
91.5
monocyte percentage of leukocytes
2
88
leukocyte count
3
70.2
central corneal thickness
0
2.9
69.8
lymphocyte percentage of leukocytes
1
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1919330
72080
Rat
RGD:1590629
680531
Dog
suppressor APC domain containing 2
VGNC:45864
491240
Cow
suppressor APC domain containing 2
VGNC:34285
100299080
Opossum
suppressor APC domain containing 2 [Source:HGNC Symbol;Acc:HGNC:28055]
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
suppressor APC domain containing 2
Cow
suppressor APC domain containing 2
Opossum
suppressor APC domain containing 2 [Source:HGNC Symbol;Acc:HGNC:28055]
Publication Statistics
PubMed Score 23.66
PubMed score by year
PubTator Score 11.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title