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Tbio
SAP30L
Histone deacetylase complex subunit SAP30L

Protein Summary
Description
Isoform 1: Functions as transcription repressor, probably via its interaction with histone deacetylase complexes (PubMed:16820529, PubMed:18070604). Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus (PubMed:16820529). Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA (PubMed:19015240). Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import (PubMed:19015240, PubMed:26609676). Isoform 2: Functions as transcription repressor; isoform 2 has lower transcription repressor activity than isoform 1 and isoform 3. Isoform 3: Functions as transcription repressor; its activity is marginally lower than that of isoform 1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297109
  • ENSP00000297109
  • ENSG00000164576
  • ENST00000426761
  • ENSP00000416393
  • ENST00000440364
  • ENSP00000390927

Symbol
  • NS4ATP2
  • NS4ATP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.87
histone modification site profile
0.75
gene perturbation
0.68
tissue sample
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.35   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.35   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (109)
SINHCAF
Tdark
Novelty:  0.18692832
p_int:  0.9999997
p_ni:  2.54e-7
p_wrong:  4.6e-8
Score:  0.968
Data Source:  BioPlex,STRINGDB
RBBP7
Tbio
Novelty:  0.01795364
p_int:  0.999999363
p_ni:  6.35e-7
p_wrong:  2e-9
Score:  0.975
Data Source:  BioPlex,STRINGDB
ING2
Tchem
Family:  Epigenetic
Novelty:  0.02424031
p_int:  0.999992326
p_ni:  0.000007649
p_wrong:  2.5e-8
Score:  0.989
Data Source:  BioPlex,STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.999986402
p_ni:  0.000013556
p_wrong:  4.2e-8
Score:  0.96
Data Source:  BioPlex,STRINGDB
ZNF704
Tdark
Novelty:  0.34442716
p_int:  0.999903956
p_ni:  0.000094918
p_wrong:  0.000001126
Score:  0.65
Data Source:  BioPlex,STRINGDB
MXD3
Tbio
Family:  TF
Novelty:  0.07436584
p_int:  0.99967001
p_ni:  0.000328884
p_wrong:  0.000001106
Score:  0.535
Data Source:  BioPlex,STRINGDB
MXD1
Tbio
Family:  TF
Novelty:  0.0353468
p_int:  0.904089858
p_ni:  0.00012218
p_wrong:  0.095787962
Score:  0.28
Data Source:  BioPlex,STRINGDB
SIN3A
Tbio
Novelty:  0.00747207
Score:  0.985
Data Source:  STRINGDB
SUDS3
Tbio
Family:  Enzyme
Novelty:  0.03837881
Score:  0.977
Data Source:  STRINGDB
SAP18
Tbio
Family:  Enzyme
Novelty:  0.03918373
Score:  0.975
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Reactome
HDACs deacetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Epigenetic regulation of gene expression
Gene expression (Transcription)
HDACs deacetylate histones
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
2
4
11
88.6
balding measurement
1
3
3
71.5
synophrys measurement
1
1
1
34.9
triglyceride measurement
1
1
1
28.1
QRS amplitude
1
1
0
38.4
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
11
88.6
balding measurement
3
71.5
synophrys measurement
1
34.9
triglyceride measurement
1
28.1
QRS amplitude
0
38.4
28.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SAP30 like
VGNC:14163
462208
Macaque
SAP30 like
714400
Mouse
MGI:1354709
50724
Rat
RGD:1309585
360531
Dog
SAP30 like
VGNC:45862
612111
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SAP30 like
Macaque
SAP30 like
Mouse
Rat
Dog
SAP30 like
Publication Statistics
PubMed Score 6.35
PubMed score by year
PubTator Score 4.15
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title