Tbio SAMM50 Sorting and assembly machinery component 50 homolog

Protein Summary

Description

Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes (PubMed:22252321, PubMed:25781180). Required for the assembly of TOMM40 into the TOM complex (PubMed:15644312). This gene encodes a component of the Sorting and Assembly Machinery (SAM) of the mitochondrial outer membrane. The Sam complex functions in the assembly of beta-barrel proteins into the outer mitochondrial membrane.[provided by RefSeq, Jun 2011]

Uniprot Accession IDs

• Q9Y512
• Q53HC4
• Q56VW7
• Q969Y9
• Q96I46
• Q9NW85
• Q9UQM9

Gene Name

• SAMM50

Ensembl ID

• ENST00000350028
• ENSP00000345445
• ENSG00000100347

Symbol

• SAM50
• OMP85
• SAM50
• TOB55
• TRG-3
• CGI-51
• YNL026W

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.98
disease perturbation	0.9
histone modification site profile	0.88
virus perturbation	0.85
transcription factor perturbation	0.84

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 220.34   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 159   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 220.34   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0