Tbio SAMD9L Sterile alpha motif domain-containing protein 9-like

Protein Summary

Description

May be involved in endosome fusion. Mediates down-regulation of growth factor signaling via internalization of growth factor receptors. This gene encodes a cytoplasmic protein that acts as a tumor suppressor but also plays a key role in cell proliferation and the innate immune response to viral infection. The encoded protein contains an N-terminal sterile alpha motif domain. Naturally occurring mutations in this gene are associated with myeloid disorders such as juvenile myelomonocytic leukemia, acute myeloid leukemia, and myelodysplastic syndrome. Naturally occurring mutations are also associated with hepatitis-B related hepatocellular carcinoma, normophosphatemic familial tumoral calcinosis, and ataxia-pancytopenia syndrome. [provided by RefSeq, Apr 2017]

Uniprot Accession IDs

• Q8IVG5
• A0JP23
• A0JP24
• A0PJG8
• A4D1G8
• D6W5Q6
• Q2TV71
• Q2TV75
• Q2UZV8
• Q8IWI4
• Q8N3L9
• Q8N875
• SAM domain-containing protein 9-like

Gene Name

• SAMD9L

Ensembl ID

• ENST00000318238
• ENSP00000326247
• ENSG00000177409
• ENST00000411955
• ENSP00000405760
• ENST00000437805
• ENSP00000408796
• ENST00000610760
• ENSP00000484397

Symbol

• C7orf6
• DRIF2
• KIAA2005
• UEF
• UEF1
• ATXPC
• DRIF2
• C7orf6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
gene perturbation	0.63
tissue sample	0.62
interacting protein	0.57
cell line	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.23   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 101   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.23   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0