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Tdark
SAMD7
Sterile alpha motif domain-containing protein 7

Protein Summary
Description
Involved in the regulation of gene expression in the retina. It functions as a negative regulator of CRX-controlled genes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335556
  • ENSP00000334668
  • ENSG00000187033
  • ENST00000428432
  • ENSP00000391299
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.61
cellular component
0.52
cell type or tissue
0.49
microRNA
0.42
protein domain
0.41


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.08   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.08   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (20)
SAMD11
Tdark
Novelty:  0.32977476
p_int:  0.999973946
p_ni:  0.000026054
Score:  0.483
Data Source:  BioPlex,STRINGDB
GAPDHS
Tbio
Family:  Enzyme
Novelty:  0.00885959
p_int:  0.983490885
p_ni:  0.01650908
p_wrong:  3.5e-8
Score:  0.2
Data Source:  BioPlex,STRINGDB
FBP1
Tchem
Family:  Enzyme
Novelty:  0.0029987
p_int:  0.954356049
p_ni:  0.045643951
Score:  0.19
Data Source:  BioPlex,STRINGDB
KLHL15
Tbio
Novelty:  0.54712519
p_int:  0.866203184
p_ni:  0.133796816
Score:  0.169
Data Source:  BioPlex,STRINGDB
SAMD10
Tdark
Novelty:  2.02197004
Score:  0.757
Data Source:  STRINGDB
SAMD5
Tdark
Novelty:  0.13397017
Score:  0.744
Data Source:  STRINGDB
ANKRD33
Tdark
Novelty:  0.48399632
Score:  0.621
Data Source:  STRINGDB
CRX
Tbio
Family:  TF
Novelty:  0.00278097
Score:  0.615
Data Source:  STRINGDB
SMAD7
Tbio
Family:  TF
Novelty:  0.00116343
Score:  0.574
Data Source:  STRINGDB
PCBP4
Tbio
Novelty:  0.03763262
Score:  0.564
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cup-to-disc ratio measurement
1
1
1
67.6
1
1
0
1.3
53.3
1
1
0
1.2
50.9
mean corpuscular volume
1
1
1
45.5
monocyte percentage of leukocytes
1
1
1
30.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cup-to-disc ratio measurement
1
67.6
0
1.3
53.3
0
1.2
50.9
mean corpuscular volume
1
45.5
monocyte percentage of leukocytes
1
30.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sterile alpha motif domain containing 7
VGNC:2545
470993
Mouse
MGI:1923203
75953
Rat
RGD:1308931
310257
Dog
sterile alpha motif domain containing 7
VGNC:45854
488156
Horse
sterile alpha motif domain containing 7
VGNC:22679
100057525
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sterile alpha motif domain containing 7
Mouse
Rat
Dog
sterile alpha motif domain containing 7
Horse
sterile alpha motif domain containing 7
Publication Statistics
PubMed Score 3.08
PubMed score by year
PubTator Score 0.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title