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Tbio
SAMD4B
Protein Smaug homolog 2

Protein Summary
Description
Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314471
  • ENSP00000317224
  • ENSG00000179134
  • ENST00000610417
  • ENSP00000484229

Symbol
  • SMAUG2
  • SMGB
  • Smaug2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.75
cell type or tissue
0.7
microRNA
0.7
transcription factor
0.67
histone modification site profile
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.9   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.9   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
SAMD4A
Tbio
Novelty:  0.04440962
p_int:  0.999999991
p_ni:  9e-9
Score:  0.845
Data Source:  BioPlex,STRINGDB
PDP1
Tbio
Family:  Enzyme
Novelty:  0.00442352
p_int:  0.998709582
p_ni:  0.001290418
Score:  0.769
Data Source:  BioPlex,STRINGDB
YWHAG
Tchem
Novelty:  0.00845572
p_int:  0.965642736
p_ni:  0.034357264
Score:  0.305
Data Source:  BioPlex,STRINGDB
YWHAE
Tbio
Novelty:  0.00431876
p_int:  0.874613161
p_ni:  0.125386839
Score:  0.656
Data Source:  BioPlex,STRINGDB
ACTA2
Tbio
Novelty:  0.00199354
p_int:  0.850515123
p_ni:  0.149484877
Data Source:  BioPlex
YWHAZ
Tchem
Novelty:  0.00210582
p_int:  0.778117156
p_ni:  0.221882844
Score:  0.352
Data Source:  BioPlex,STRINGDB
YWHAB
Tchem
Novelty:  0.00614093
p_int:  0.767967262
p_ni:  0.232032738
Score:  0.6
Data Source:  BioPlex,STRINGDB
FBXO33
Tdark
Novelty:  0.23409767
Score:  0.723
Data Source:  STRINGDB
USH1G
Tbio
Novelty:  0.02912203
Score:  0.715
Data Source:  STRINGDB
USH1C
Tbio
Novelty:  0.01066917
Score:  0.628
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
3
0
2.2
91.3
remission
3
1
0
2.1
84.2
3
1
0
2.1
84.2
neutrophil count
2
2
2
77
myeloid white cell count
1
1
1
62.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2.2
91.3
remission
0
2.1
84.2
0
2.1
84.2
neutrophil count
2
77
myeloid white cell count
1
62.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sterile alpha motif domain containing 4B
VGNC:2255
456020
Macaque
sterile alpha motif domain containing 4B
696615
Mouse
MGI:2448542
233033
Rat
RGD:1305597
308473
Dog
sterile alpha motif domain containing 4B
VGNC:45853
484511
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sterile alpha motif domain containing 4B
Macaque
sterile alpha motif domain containing 4B
Mouse
Rat
Dog
sterile alpha motif domain containing 4B
Publication Statistics
PubMed Score 9.90
PubMed score by year
PubTator Score 5.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title