Tbio SAMD4B Protein Smaug homolog 2

Protein Summary

Description

Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A.

Uniprot Accession IDs

• Q5PRF9
• A5Z0M6
• Q6P194
• Smaug 2

Gene Name

• SAMD4B

Ensembl ID

• ENST00000314471
• ENSP00000317224
• ENSG00000179134
• ENST00000610417
• ENSP00000484229

Symbol

• SMAUG2
• SMGB
• Smaug2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.75
cell type or tissue	0.7
microRNA	0.7
transcription factor	0.67
histone modification site profile	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.9   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 130   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.9   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (38)

Explore Interacting Targets

1 – 10 of 38

• See Interactions on String-DB

SAMD4A

Tbio

Novelty:  0.04440962

p_int:  0.999999991

p_ni:  9e-9

Score:  0.845

Data Source:  BioPlex,STRINGDB

PDP1

Tbio

Family:  Enzyme

Novelty:  0.00442352

p_int:  0.998709582

p_ni:  0.001290418

Score:  0.769

Data Source:  BioPlex,STRINGDB

YWHAG

Tchem

Novelty:  0.00845572

p_int:  0.965642736

p_ni:  0.034357264

Score:  0.305

Data Source:  BioPlex,STRINGDB

YWHAE

Tbio

Novelty:  0.00431876

p_int:  0.874613161

p_ni:  0.125386839

Score:  0.656

Data Source:  BioPlex,STRINGDB

ACTA2

Tbio

Novelty:  0.00199354

p_int:  0.850515123

p_ni:  0.149484877

Data Source:  BioPlex

YWHAZ

Tchem

Novelty:  0.00210582

p_int:  0.778117156

p_ni:  0.221882844

Score:  0.352

Data Source:  BioPlex,STRINGDB

YWHAB

Tchem

Novelty:  0.00614093

p_int:  0.767967262

p_ni:  0.232032738

Score:  0.6

Data Source:  BioPlex,STRINGDB

FBXO33

Tdark

Novelty:  0.23409767

Score:  0.723

Data Source:  STRINGDB

USH1G

Tbio

Novelty:  0.02912203

Score:  0.715

Data Source:  STRINGDB

USH1C

Tbio

Novelty:  0.01066917

Score:  0.628

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (9)

Functions (3)

Components (3)

Processes (3)

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1 – 3 of 3

GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
mRNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
translation repressor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (10)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 10

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
chronic hepatitis C virus infection	EFO_0004220	7	3	0	2.2	91.3
remission	EFO_0009785	3	1	0	2.1	84.2
hepatitis C virus infection	EFO_0003047	3	1	0	2.1	84.2
neutrophil count	EFO_0004833	2	2	2		77
myeloid white cell count	EFO_0007988	1	1	1		62.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 10

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
chronic hepatitis C virus infection	EFO_0004220	0	2.2	91.3
remission	EFO_0009785	0	2.1	84.2
hepatitis C virus infection	EFO_0003047	0	2.1	84.2
neutrophil count	EFO_0004833	2		77
myeloid white cell count	EFO_0007988	1		62.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
Cytoplasm
Methylation
Nucleus
Phosphoprotein
Reference proteome
Repressor
Transcription
Transcription regulation

GWAS Trait Find Similar Targets

No Header	No Header
chronic hepatitis C virus infection
hepatitis C virus infection
hepatocellular carcinoma
leukocyte count
mathematical ability
mitochondrial heteroplasmy measurement
myeloid white cell count
neutrophil count
remission
viral load

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	sterile alpha motif domain containing 4B	VGNC:2255	456020
Macaque	sterile alpha motif domain containing 4B		696615
Mouse	sterile alpha motif domain containing 4B	MGI:2448542	233033
Rat	sterile alpha motif domain containing 4B	RGD:1305597	308473
Dog	sterile alpha motif domain containing 4B	VGNC:45853	484511

Species	Name	OMA	EggNOG	Inparanoid
Chimp	sterile alpha motif domain containing 4B
Macaque	sterile alpha motif domain containing 4B
Mouse	sterile alpha motif domain containing 4B
Rat	sterile alpha motif domain containing 4B
Dog	sterile alpha motif domain containing 4B

Publication Statistics

PubMed Score 9.90

PubMed score by year

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PubTator Score 5.67

PubTator score by year

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Related Publications

Text Mined References (16)

GeneRif Annotations (3)

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PMID	Year	Title