Tbio SAMD4A Protein Smaug homolog 1

Protein Summary

Description

Acts as a translational repressor of SRE-containing messengers. Sterile alpha motifs (SAMs) in proteins such as SAMD4A are part of an RNA-binding domain that functions as a posttranscriptional regulator by binding to an RNA sequence motif known as the Smaug recognition element, which was named after the Drosophila Smaug protein (Baez and Boccaccio, 2005 [PubMed 16221671]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q9UPU9
• A8MPZ5
• Q0VA96
• Q6PEW4
• Smaug 1

Gene Name

• SAMD4A

Ensembl ID

• ENST00000251091
• ENSP00000251091
• ENSG00000020577
• ENST00000392067
• ENSP00000375919
• ENST00000554335
• ENSP00000452535

Symbol

• KIAA1053
• SAMD4
• SMAUG1
• SMG
• SMGA
• SAMD4
• SMAUG
• SMAUG1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.99
transcription factor binding site profile	0.92
virus perturbation	0.9
transcription factor	0.82
small molecule perturbation	0.77

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.1   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 84   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.1   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0