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Tbio
SAMD4A
Protein Smaug homolog 1

Protein Summary
Description
Acts as a translational repressor of SRE-containing messengers. Sterile alpha motifs (SAMs) in proteins such as SAMD4A are part of an RNA-binding domain that functions as a posttranscriptional regulator by binding to an RNA sequence motif known as the Smaug recognition element, which was named after the Drosophila Smaug protein (Baez and Boccaccio, 2005 [PubMed 16221671]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251091
  • ENSP00000251091
  • ENSG00000020577
  • ENST00000392067
  • ENSP00000375919
  • ENST00000554335
  • ENSP00000452535

Symbol
  • KIAA1053
  • SAMD4
  • SMAUG1
  • SMG
  • SMGA
  • SAMD4
  • SMAUG
  • SMAUG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
transcription factor binding site profile
0.92
virus perturbation
0.9
transcription factor
0.82
small molecule perturbation
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.23   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.23   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
SAMD4B
Tbio
Novelty:  0.10461155
p_int:  0.999999991
p_ni:  9e-9
Score:  0.845
Data Source:  BioPlex,STRINGDB
INPPL1
Tchem
Family:  Enzyme
Novelty:  0.00634126
p_int:  0.9999457
p_ni:  0.0000543
Score:  0.15
Data Source:  BioPlex,STRINGDB
TNIP1
Tbio
Novelty:  0.0147254
p_int:  0.99984588
p_ni:  0.000154117
p_wrong:  3e-9
Score:  0.179
Data Source:  BioPlex,STRINGDB
YWHAZ
Tchem
Novelty:  0.00210582
p_int:  0.996991861
p_ni:  0.003008139
Score:  0.165
Data Source:  BioPlex,STRINGDB
YWHAE
Tbio
Novelty:  0.00431876
p_int:  0.992584548
p_ni:  0.007415452
Score:  0.307
Data Source:  BioPlex,STRINGDB
YWHAB
Tchem
Novelty:  0.00614093
p_int:  0.965259315
p_ni:  0.034740685
Score:  0.51
Data Source:  BioPlex,STRINGDB
DDB2
Tbio
Novelty:  0.00648809
p_int:  0.955398081
p_ni:  0.044356915
p_wrong:  0.000245004
Score:  0.184
Data Source:  BioPlex,STRINGDB
YWHAH
Tchem
Novelty:  0.01000071
p_int:  0.925524414
p_ni:  0.074475586
Score:  0.169
Data Source:  BioPlex,STRINGDB
CSDE1
Tbio
Family:  TF
Novelty:  0.02625299
p_int:  0.923271907
p_ni:  0.076728093
Score:  0.228
Data Source:  BioPlex,STRINGDB
YWHAG
Tchem
Novelty:  0.00845572
p_int:  0.909240577
p_ni:  0.090759423
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatine kinase measurement
1
3
3
90.2
mean corpuscular hemoglobin concentration
1
1
1
66.8
4
1
1
1.1
66
aspartate aminotransferase measurement
1
1
0
8.1
66
mathematical ability
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatine kinase measurement
3
90.2
mean corpuscular hemoglobin concentration
1
66.8
1
1.1
66
aspartate aminotransferase measurement
0
8.1
66
mathematical ability
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
sterile alpha motif domain containing 4A
695336
Mouse
MGI:1921730
74480
Rat
RGD:1310361
305826
Dog
sterile alpha motif domain containing 4A
VGNC:45852
490700
Cow
sterile alpha motif domain containing 4A
VGNC:34272
540852
Species
Name
OMA
EggNOG
Inparanoid
Macaque
sterile alpha motif domain containing 4A
Mouse
Rat
Dog
sterile alpha motif domain containing 4A
Cow
sterile alpha motif domain containing 4A
Publication Statistics
PubMed Score 26.23
PubMed score by year
PubTator Score 25.97
PubTator score by year
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Related Publications
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PMID
Year
Title