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Tbio
SAFB2
Scaffold attachment factor B2

Protein Summary
Description
Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. The protein encoded by this gene, along with its paralog (scaffold attachment factor B1), is a repressor of estrogen receptor alpha. The encoded protein binds scaffold/matrix attachment region (S/MAR) DNA and is involved in cell cycle regulation, apoptosis, differentiation, the stress response, and regulation of immune genes. [provided by RefSeq, May 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252542
  • ENSP00000252542
  • ENSG00000130254
  • ENST00000591120
  • ENSP00000468505

Symbol
  • KIAA0138
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.79
gene perturbation
0.76
transcription factor perturbation
0.74
transcription factor
0.69
tissue sample
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.27   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.27   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
ELAVL2
Tbio
Novelty:  0.00370708
p_int:  0.999838344
p_ni:  0.000161656
Data Source:  BioPlex
DHPS
Tchem
Family:  Enzyme
Novelty:  0.00776893
p_int:  0.99978159
p_ni:  0.00021841
Score:  0.17
Data Source:  BioPlex,STRINGDB
TRIP6
Tbio
Novelty:  0.02183202
p_int:  0.998648108
p_ni:  0.001351892
Score:  0.16
Data Source:  BioPlex,STRINGDB
APOBEC3D
Tbio
Novelty:  0.01102619
p_int:  0.998154039
p_ni:  0.001845961
Data Source:  BioPlex
CAPN13
Tdark
Novelty:  0.27206398
p_int:  0.996806663
p_ni:  0.003193337
Score:  0.189
Data Source:  BioPlex,STRINGDB
CIZ1
Tbio
Novelty:  0.03730538
p_int:  0.992865847
p_ni:  0.007134129
p_wrong:  2.4e-8
Score:  0.546
Data Source:  BioPlex,STRINGDB
ZFP41
Tdark
Family:  TF
Novelty:  3.33093006
p_int:  0.988465447
p_ni:  0.011534552
p_wrong:  1e-9
Data Source:  BioPlex
CLK3
Tchem
Family:  Kinase
Novelty:  0.03466191
p_int:  0.94170929
p_ni:  0.05829071
Score:  0.177
Data Source:  BioPlex,STRINGDB
COPZ1
Tbio
Novelty:  0.01405958
p_int:  0.936622267
p_ni:  0.063377372
p_wrong:  3.61e-7
Data Source:  BioPlex
LARP4B
Tbio
Novelty:  0.11363794
p_int:  0.890799298
p_ni:  0.109200699
p_wrong:  4e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mitochondrial DNA measurement
1
3
3
94
mean corpuscular hemoglobin concentration
1
1
1
75.2
red blood cell distribution width
2
2
2
66.6
mean corpuscular volume
1
1
1
59.6
mean reticulocyte volume
1
1
1
52
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mitochondrial DNA measurement
3
94
mean corpuscular hemoglobin concentration
1
75.2
red blood cell distribution width
2
66.6
mean corpuscular volume
1
59.6
mean reticulocyte volume
1
52
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
scaffold attachment factor B2
VGNC:2257
455618
Macaque
scaffold attachment factor B2
696236
Mouse
MGI:2146808
224902
Dog
scaffold attachment factor B2
VGNC:45845
476740
Horse
scaffold attachment factor B2
VGNC:22668
100064922
Species
Name
OMA
EggNOG
Inparanoid
Chimp
scaffold attachment factor B2
Macaque
scaffold attachment factor B2
Mouse
Dog
scaffold attachment factor B2
Horse
scaffold attachment factor B2
Publication Statistics
PubMed Score 7.27
PubMed score by year
PubTator Score 9.82
PubTator score by year
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Related Publications
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PMID
Year
Title