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Tbio
SAE1
SUMO-activating enzyme subunit 1

Protein Summary
Description
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270225
  • ENSP00000270225
  • ENSG00000142230
  • ENST00000392776
  • ENSP00000440818
  • ENST00000413379
  • ENSP00000416557

Symbol
  • AOS1
  • SUA1
  • UBLE1A
  • AOS1
  • SUA1
  • UBLE1A
  • HSPC140
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
hub protein
0.88
transcription factor perturbation
0.84
transcription factor binding site profile
0.83
tissue sample
0.71


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.4   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 480   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.4   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 480   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (131)
UBA2
Tbio
Novelty:  0.01582807
p_int:  0.999962977
p_ni:  0.000037023
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
UBE2I
Tbio
Novelty:  0.00267883
p_int:  0.994110423
p_ni:  0.005889577
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
SUMO2
Tbio
Novelty:  0.00366833
Score:  0.999
Data Source:  Reactome,STRINGDB
SUMO1
Tbio
Novelty:  0.00137629
Score:  0.999
Data Source:  Reactome,STRINGDB
SUMO3
Tbio
Novelty:  0.03096465
Score:  0.997
Data Source:  Reactome,STRINGDB
SUMO4
Tbio
Novelty:  0.01534859
Score:  0.951
Data Source:  STRINGDB
RWDD3
Tbio
Novelty:  0.07031976
Score:  0.926
Data Source:  STRINGDB
CUL1
Tbio
Novelty:  0.00244476
Score:  0.926
Data Source:  STRINGDB
RBX1
Tbio
Family:  Enzyme
Novelty:  0.00596986
Score:  0.923
Data Source:  STRINGDB
UBE2M
Tchem
Novelty:  0.02353106
Score:  0.923
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Metabolism of proteins (R-HSA-392499)

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Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Processing and activation of SUMO
Reactome
SUMO is conjugated to E1 (UBA2:SAE1)
Reactome
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
Processing and activation of SUMO
SUMO is conjugated to E1 (UBA2:SAE1)
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CAFA
Inferred from Physical Interaction (IPI)
CAFA
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (36)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
3
3
95.5
hematocrit
3
3
3
93.3
body mass index
12
5
17
93
hemoglobin measurement
3
3
3
92.2
body height
2
2
2
89.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
95.5
hematocrit
3
93.3
body mass index
17
93
hemoglobin measurement
3
92.2
body height
2
89.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SUMO1 activating enzyme subunit 1
VGNC:2259
456159
Macaque
SUMO1 activating enzyme subunit 1
717918
Mouse
MGI:1929264
56459
Rat
RGD:1306098
308384
Dog
SUMO1 activating enzyme subunit 1
VGNC:45843
476425
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SUMO1 activating enzyme subunit 1
Macaque
SUMO1 activating enzyme subunit 1
Mouse
Rat
Dog
SUMO1 activating enzyme subunit 1
Publication Statistics
PubMed Score 55.40
PubMed score by year
PubTator Score 28.94
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title