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Tdark
SAAL1
Protein SAAL1

Protein Summary
Description
Plays a role in promoting the proliferation of synovial fibroblasts in response to proinflammatory stimuli.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000524803
  • ENSP00000432487
  • ENSG00000166788

Symbol
  • SPACIA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.74
kinase perturbation
0.71
histone modification site profile
0.7
virus perturbation
0.64
transcription factor
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.71   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.71   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
SNW1
Tbio
Novelty:  0.01423797
p_int:  0.998444945
p_ni:  0.00155499
p_wrong:  6.5e-8
Score:  0.152
Data Source:  BioPlex,STRINGDB
EPHA1
Tchem
Family:  Kinase
Novelty:  0.00136672
p_int:  0.997533386
p_ni:  0.002466614
p_wrong:  1e-9
Data Source:  BioPlex
TMEM206
Tdark
Novelty:  0.17311172
p_int:  0.984351218
p_ni:  0.01564878
p_wrong:  1e-9
Data Source:  BioPlex
VSIG2
Tdark
Novelty:  0.32398032
p_int:  0.979284244
p_ni:  0.020715756
Data Source:  BioPlex
VASN
Tbio
Novelty:  0.05424159
p_int:  0.973207957
p_ni:  0.026791819
p_wrong:  2.25e-7
Data Source:  BioPlex
PNKD
Tbio
Family:  Enzyme
Novelty:  0.02456078
p_int:  0.971909688
p_ni:  0.028090312
Data Source:  BioPlex
ST6GAL1
Tchem
Family:  Enzyme
Novelty:  0.00274127
p_int:  0.966531645
p_ni:  0.033468339
p_wrong:  1.6e-8
Data Source:  BioPlex
UXS1
Tbio
Family:  Enzyme
Novelty:  0.04671281
p_int:  0.966321601
p_ni:  0.033678399
Data Source:  BioPlex
TPST2
Tbio
Family:  Enzyme
Novelty:  0.02551048
p_int:  0.9620178
p_ni:  0.0379822
p_wrong:  1e-9
Data Source:  BioPlex
SIGLECL1
Tdark
p_int:  0.960184703
p_ni:  0.039815085
p_wrong:  2.12e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
1
1
1
27.3
high density lipoprotein cholesterol measurement
1
1
1
21.5
myeloid white cell count
1
1
1
13.3
neutrophil count
1
1
1
11.4
testosterone measurement
1
1
1
8.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
1
27.3
high density lipoprotein cholesterol measurement
1
21.5
myeloid white cell count
1
13.3
neutrophil count
1
11.4
testosterone measurement
1
8.3
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serum amyloid A like 1
VGNC:3059
748800
Macaque
serum amyloid A like 1
695747
Mouse
MGI:1926185
78935
Dog
serum amyloid A like 1
VGNC:45839
611958
Horse
serum amyloid A like 1
VGNC:22663
100071828
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serum amyloid A like 1
Macaque
serum amyloid A like 1
Mouse
Dog
serum amyloid A like 1
Horse
serum amyloid A like 1
Publication Statistics
PubMed Score 3.71
PubMed score by year
PubTator Score 0.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title