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Tclin
S1PR4
Sphingosine 1-phosphate receptor 4

Protein Summary
Description
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes. This gene is a member of the endothelial differentiation, G-protein-coupled (EDG)) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246115
  • ENSP00000246115
  • ENSG00000125910

Symbol
  • EDG6
  • EDG6
  • LPC1
  • S1P4
  • SLP4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.64
protein domain
0.58
disease perturbation
0.56
cell type or tissue
0.51
tissue
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.67   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 350   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.67   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 350   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 115
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (115)
sphingosine 1-phosphate
Rendered image for sphingosine 1-phosphate
CHEMBL3769933
Rendered image for CHEMBL3769933
fingolimod-phosphate
Rendered image for fingolimod-phosphate
Fingolimod phosphate
Rendered image for Fingolimod phosphate
ASP4058
Rendered image for ASP4058
CHEMBL194419
Rendered image for CHEMBL194419
CHEMBL1091103
Rendered image for CHEMBL1091103
FTY720-P(R)
Rendered image for FTY720-P(R)
Protein-Protein Interactions (315)
TBC1D24
Tbio
Novelty:  0.0161631
p_int:  0.996766898
p_ni:  0.003057862
p_wrong:  0.00017524
Score:  0.269
Data Source:  BioPlex,STRINGDB
PITPNA
Tbio
Novelty:  0.01901136
p_int:  0.77908597
p_ni:  0.22091403
Score:  0.692
Data Source:  BioPlex,STRINGDB
CCR7
Tchem
Family:  GPCR
Novelty:  0.00084453
Score:  0.972
Data Source:  STRINGDB
GPSM3
Tbio
Novelty:  0.01632501
Score:  0.952
Data Source:  STRINGDB
LPAR5
Tchem
Family:  GPCR
Novelty:  0.01883439
Score:  0.949
Data Source:  STRINGDB
P2RY14
Tchem
Family:  GPCR
Novelty:  0.0135462
Score:  0.936
Data Source:  STRINGDB
GNA12
Tbio
Novelty:  0.06310884
Score:  0.935
Data Source:  STRINGDB
GNA13
Tbio
Novelty:  0.04149138
Score:  0.935
Data Source:  STRINGDB
GNAI1
Tbio
Novelty:  0.0488971
Score:  0.935
Data Source:  STRINGDB
CXCR4
Tclin
Family:  GPCR
Novelty:  0.0002811
Score:  0.933
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (43)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Lysosphingolipid and LPA receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Lysosphingolipid and LPA receptors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
4
4
5
97.9
leukocyte count
2
4
4
97.8
myeloid white cell count
2
2
2
95.4
eosinophil count
3
2
4
92.2
eosinophil percentage of leukocytes
2
2
3
90.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
5
97.9
leukocyte count
4
97.8
myeloid white cell count
2
95.4
eosinophil count
4
92.2
eosinophil percentage of leukocytes
3
90.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
-
Mouse
MGI:1333809
13611
Rat
RGD:1304801
314649
Horse
sphingosine-1-phosphate receptor 4 [Source:HGNC Symbol;Acc:HGNC:3170]
Cow
sphingosine-1-phosphate receptor 4
VGNC:34255
539534
Species
Name
OMA
EggNOG
Inparanoid
Macaque
-
Mouse
Rat
Horse
sphingosine-1-phosphate receptor 4 [Source:HGNC Symbol;Acc:HGNC:3170]
Cow
sphingosine-1-phosphate receptor 4
Publication Statistics
PubMed Score 57.67
PubMed score by year
PubTator Score 34.10
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title