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Tchem
S1PR2
Sphingosine 1-phosphate receptor 2

Protein Summary
Description
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P) (PubMed:10617617). S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues (PubMed:10617617). When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis (PubMed:10617617). Receptor for the chemokine-like protein FAM19A5 (PubMed:29453251). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity). This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. The encoded protein is a receptor for sphingosine 1-phosphate, which participates in cell proliferation, survival, and transcriptional activation. Defects in this gene have been associated with congenital profound deafness. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000590320
  • ENSP00000466933
  • ENSG00000267534
  • ENST00000646641
  • ENSP00000496438

Symbol
  • EDG5
  • EDG5
  • H218
  • LPB2
  • S1P2
  • AGR16
  • EDG-5
  • DFNB68
  • Gpcr13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.79
transcription factor
0.71
microRNA
0.7
biological process
0.64
molecular function
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 299.79   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 290   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 299.79   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 290   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 102
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (102)
Protein-Protein Interactions (287)
C8G
Tbio
Novelty:  0.02322575
p_int:  0.999988155
p_ni:  1.2e-7
p_wrong:  0.000011724
Score:  0.189
Data Source:  BioPlex,STRINGDB
NDRG1
Tbio
Novelty:  0.00352631
p_int:  0.99973262
p_ni:  0.000267321
p_wrong:  5.9e-8
Score:  0.159
Data Source:  BioPlex,STRINGDB
TNFSF18
Tbio
Novelty:  0.01423949
p_int:  0.999589336
p_ni:  0.000011527
p_wrong:  0.000399137
Data Source:  BioPlex
FKBP14
Tbio
Family:  Enzyme
Novelty:  0.02742616
p_int:  0.999251981
p_ni:  0.000747953
p_wrong:  6.5e-8
Data Source:  BioPlex
PALM3
Tbio
Novelty:  0.07224273
p_int:  0.997074551
p_ni:  0.001260304
p_wrong:  0.001665145
Score:  0.248
Data Source:  BioPlex,STRINGDB
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
p_int:  0.99531554
p_ni:  0.004237289
p_wrong:  0.000447171
Score:  0.354
Data Source:  BioPlex,STRINGDB
HPCAL1
Tbio
Novelty:  0.04434155
p_int:  0.995221222
p_ni:  0.004752144
p_wrong:  0.000026634
Data Source:  BioPlex
ARL6IP5
Tbio
Novelty:  0.00871985
p_int:  0.994735352
p_ni:  0.005264648
Data Source:  BioPlex
WDFY1
Tbio
Novelty:  0.13382544
p_int:  0.976587365
p_ni:  0.023412626
p_wrong:  9e-9
Data Source:  BioPlex
LGALS1
Tchem
Novelty:  0.00106509
p_int:  0.976311571
p_ni:  0.023688309
p_wrong:  1.2e-7
Data Source:  BioPlex
Pathways (19)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Lysosphingolipid and LPA receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Lysosphingolipid and LPA receptors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (29)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
ICAM-1 measurement
2
3
0
13.8
97.6
IGF-1 measurement
1
4
4
96.7
reticulocyte count
7
7
13
95.2
myeloid white cell count
2
2
2
91.5
reticulocyte measurement
3
4
8
90.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
ICAM-1 measurement
0
13.8
97.6
IGF-1 measurement
4
96.7
reticulocyte count
13
95.2
myeloid white cell count
2
91.5
reticulocyte measurement
8
90.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sphingosine-1-phosphate receptor 2
VGNC:12084
107966508
Macaque
sphingosine-1-phosphate receptor 2
712143
Mouse
MGI:99569
14739
Rat
RGD:68334
29415
Horse
sphingosine-1-phosphate receptor 2
VGNC:22661
100058299
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sphingosine-1-phosphate receptor 2
Macaque
sphingosine-1-phosphate receptor 2
Mouse
Rat
Horse
sphingosine-1-phosphate receptor 2
Publication Statistics
PubMed Score 299.79
PubMed score by year
PubTator Score 121.98
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title