Tclin S1PR1 Sphingosine 1-phosphate receptor 1

Protein Summary

Description

G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury. The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Uniprot Accession IDs

• P21453
• D3DT66
• Q9BYY4
• Q9NYN8
• S1P receptor 1

Gene Name

• S1PR1

Ensembl ID

• ENST00000305352
• ENSP00000305416
• ENSG00000170989
• ENST00000475289
• ENSP00000498038
• ENST00000648480
• ENSP00000497478
• ENST00000649383
• ENSP00000497175

Symbol

• CHEDG1
• EDG1
• EDG1
• S1P1
• CD363
• ECGF1
• EDG-1
• CHEDG1
• D1S3362

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.96
microRNA	0.79
gene perturbation	0.71
transcription factor binding site profile	0.69
histone modification site profile	0.66

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Sphingosine 1-phosphate Receptor 1

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Sphingosine 1-phosphate Receptor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 794.68   (req: < 5)

Gene RIFs: 189   (req: <= 3)

Antibodies: 697   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 794.68   (req: >= 5)

Gene RIFs: 189   (req: > 3)

Antibodies: 697   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1728

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4