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Tclin
S1PR1
Sphingosine 1-phosphate receptor 1

Protein Summary
Description
G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305352
  • ENSP00000305416
  • ENSG00000170989
  • ENST00000475289
  • ENSP00000498038
  • ENST00000648480
  • ENSP00000497478
  • ENST00000649383
  • ENSP00000497175

Symbol
  • CHEDG1
  • EDG1
  • EDG1
  • S1P1
  • CD363
  • ECGF1
  • EDG-1
  • CHEDG1
  • D1S3362
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.96
microRNA
0.79
gene perturbation
0.71
transcription factor binding site profile
0.69
histone modification site profile
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 794.68   (req: < 5)
Gene RIFs: 148   (req: <= 3)
Antibodies: 697   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 794.68   (req: >= 5)
Gene RIFs: 148   (req: > 3)
Antibodies: 697   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1728
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4