You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
S100P
Protein S100-P

Protein Summary
Description
May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE). The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 4p16. This protein, in addition to binding Ca2+, also binds Zn2+ and Mg2+. This protein may play a role in the etiology of prostate can ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296370
  • ENSP00000296370
  • ENSG00000163993

Symbol
  • S100E
  • MIG9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
virus perturbation
0.95
gene perturbation
0.93
protein domain
0.73
disease
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.43   (req: < 5)
Gene RIFs: 79   (req: <= 3)
Antibodies: 293   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.43   (req: >= 5)
Gene RIFs: 79   (req: > 3)
Antibodies: 293   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (24)
MRPL53
Tdark
Novelty:  1.0076471
p_int:  0.999900302
p_ni:  0.000099684
p_wrong:  1.4e-8
Data Source:  BioPlex
GTF2A2
Tbio
Novelty:  0.03391028
p_int:  0.999856888
p_ni:  0.000143112
Data Source:  BioPlex
CCDC103
Tbio
Novelty:  0.07857649
p_int:  0.999439425
p_ni:  0.000296654
p_wrong:  0.000263921
Data Source:  BioPlex
TXNDC8
Tbio
Novelty:  0.15772943
p_int:  0.999181238
p_ni:  0.000818761
p_wrong:  1e-9
Data Source:  BioPlex
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.995107158
p_ni:  0.000316059
p_wrong:  0.004576782
Data Source:  BioPlex
NUSAP1
Tbio
Novelty:  0.01702118
p_int:  0.99116407
p_ni:  0.000370417
p_wrong:  0.008465512
Score:  0.519
Data Source:  BioPlex,STRINGDB
ZIC1
Tbio
Family:  TF
Novelty:  0.00491601
p_int:  0.990139319
p_ni:  0.000386516
p_wrong:  0.009474165
Score:  0.179
Data Source:  BioPlex,STRINGDB
PHF5A
Tbio
Family:  Epigenetic
Novelty:  0.02989472
p_int:  0.911949818
p_ni:  0.088009696
p_wrong:  0.000040485
Data Source:  BioPlex
TEFM
Tbio
Novelty:  0.10836617
p_int:  0.828431974
p_ni:  0.132268859
p_wrong:  0.039299167
Data Source:  BioPlex
S100PBP
Tbio
Novelty:  0.31210168
Score:  0.985
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
HGNC
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
HGNC
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
8.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
8.6
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
S100 calcium binding protein P
VGNC:682
742845
Macaque
S100 calcium binding protein P
710510
Dog
S100 calcium binding protein P
VGNC:45834
610295
Horse
S100 calcium binding protein P
VGNC:22657
100056472
Opossum
S100 calcium binding protein P [Source:HGNC Symbol;Acc:HGNC:10504]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
S100 calcium binding protein P
Macaque
S100 calcium binding protein P
Dog
S100 calcium binding protein P
Horse
S100 calcium binding protein P
Opossum
S100 calcium binding protein P [Source:HGNC Symbol;Acc:HGNC:10504]
Publication Statistics
PubMed Score 39.43
PubMed score by year
PubTator Score 135.05
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title