Protein Summary
Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has the highest content of cysteines of all S100 proteins, has a high affinity for Zinc, and is highly expressed in human hair cuticle. The precise function of this protein is unknown. [provided by RefSeq, Jul 2008]
- ENST00000368712
- ENSP00000357701
- ENSG00000188015
- ENST00000368713
- ENSP00000357702
- S100E
- S100E
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.95 | ||
virus perturbation | 0.76 | ||
protein domain | 0.58 | ||
tissue sample | 0.54 | ||
small molecule perturbation | 0.46 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 32.15 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 194 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 32.15 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 194 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (56)
TFG
Novelty: 0.00320616
p_int: 0.999636392
p_ni: 0.000363424
p_wrong: 1.84e-7
Score: 0.179
Data Source: BioPlex,STRINGDB
MRPL38
Novelty: 0.71587283
p_int: 0.999547133
p_ni: 0.000452746
p_wrong: 1.21e-7
Data Source: BioPlex
ELOA2
Family: Enzyme
Novelty: 0.7420148
p_int: 0.998634297
p_ni: 0.000931791
p_wrong: 0.000433912
Data Source: BioPlex
BTC
Novelty: 0.00673076
p_int: 0.997901357
p_ni: 0.00093788
p_wrong: 0.001160762
Data Source: BioPlex
PYHIN1
Novelty: 0.06662677
p_int: 0.996688516
p_ni: 0.001677663
p_wrong: 0.001633821
Score: 0.185
Data Source: BioPlex,STRINGDB
FBXO3
Novelty: 0.01701102
p_int: 0.995343336
p_ni: 0.000087026
p_wrong: 0.004569638
Data Source: BioPlex
IL31RA
Novelty: 0.00737445
p_int: 0.994606218
p_ni: 0.000539151
p_wrong: 0.004854631
Score: 0.302
Data Source: BioPlex,STRINGDB
ZMAT4
Novelty: 0.31281969
p_int: 0.992951769
p_ni: 0.000406677
p_wrong: 0.006641553
Data Source: BioPlex
OR51E2
Family: oGPCR
Novelty: 0.02435259
p_int: 0.991591764
p_ni: 0.000357072
p_wrong: 0.008051164
Score: 0.189
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (4)
Functions (2)
Components (2)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
platelet crit | 1 | 1 | 1 | 24.4 | |||||
high density lipoprotein cholesterol measurement | 1 | 1 | 1 | 6.9 | |||||
sleep duration | 1 | 1 | 1 | 6.9 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
platelet crit | 1 | 24.4 | |||||
high density lipoprotein cholesterol measurement | 1 | 6.9 | |||||
sleep duration | 1 | 6.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | S100 calcium binding protein A3 | VGNC:1525 | 100614295 | |||||
Macaque | S100 calcium binding protein A3 | 100426715 | ||||||
Mouse | MGI:1338849 | 20197 | ||||||
Rat | RGD:620260 | 114216 | ||||||
Dog | S100 calcium binding protein A3 | VGNC:45829 | 490460 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | S100 calcium binding protein A3 | |||||
Macaque | S100 calcium binding protein A3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | S100 calcium binding protein A3 | |||||
Publication Statistics
PubMed Score 32.15
PubMed score by year
PubTator Score 26.63
PubTator score by year
Related Publications
Text Mined References (22)
GeneRif Annotations (8)
Items per page:
0 of 0
PMID | Year | Title |
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