Protein Summary
Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has the highest content of cysteines of all S100 proteins, has a high affinity for Zinc, and is highly expressed in human hair cuticle. The precise function of this protein is unknown. [provided by RefSeq, Jul 2008]
- ENST00000368712
- ENSP00000357701
- ENSG00000188015
- ENST00000368713
- ENSP00000357702
- S100E
- S100E
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.95 | ||
virus perturbation | 0.76 | ||
protein domain | 0.58 | ||
tissue sample | 0.54 | ||
small molecule perturbation | 0.46 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 32.15 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 194 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 32.15 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 194 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (56)
TFG
Novelty: 0.00320616
p_int: 0.999636392
p_ni: 0.000363424
p_wrong: 1.84e-7
Score: 0.179
Data Source: BioPlex,STRINGDB
MRPL38
Novelty: 0.71587283
p_int: 0.999547133
p_ni: 0.000452746
p_wrong: 1.21e-7
Data Source: BioPlex
ELOA2
Family: Enzyme
Novelty: 0.7420148
p_int: 0.998634297
p_ni: 0.000931791
p_wrong: 0.000433912
Data Source: BioPlex
BTC
Novelty: 0.00673076
p_int: 0.997901357
p_ni: 0.00093788
p_wrong: 0.001160762
Data Source: BioPlex
PYHIN1
Novelty: 0.06662677
p_int: 0.996688516
p_ni: 0.001677663
p_wrong: 0.001633821
Score: 0.185
Data Source: BioPlex,STRINGDB
FBXO3
Novelty: 0.01701102
p_int: 0.995343336
p_ni: 0.000087026
p_wrong: 0.004569638
Data Source: BioPlex
IL31RA
Novelty: 0.00737445
p_int: 0.994606218
p_ni: 0.000539151
p_wrong: 0.004854631
Score: 0.302
Data Source: BioPlex,STRINGDB
ZMAT4
Novelty: 0.31281969
p_int: 0.992951769
p_ni: 0.000406677
p_wrong: 0.006641553
Data Source: BioPlex
OR51E2
Family: oGPCR
Novelty: 0.02435259
p_int: 0.991591764
p_ni: 0.000357072
p_wrong: 0.008051164
Score: 0.189
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (4)
Functions (2)
Components (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
platelet crit | 1 | 1 | 1 | 24.4 | |||||
high density lipoprotein cholesterol measurement | 1 | 1 | 1 | 6.9 | |||||
sleep duration | 1 | 1 | 1 | 6.9 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
platelet crit | 1 | 24.4 | |||||
high density lipoprotein cholesterol measurement | 1 | 6.9 | |||||
sleep duration | 1 | 6.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | S100 calcium binding protein A3 | VGNC:1525 | 100614295 | |||||
Macaque | S100 calcium binding protein A3 | 100426715 | ||||||
Mouse | MGI:1338849 | 20197 | ||||||
Rat | RGD:620260 | 114216 | ||||||
Dog | S100 calcium binding protein A3 | VGNC:45829 | 490460 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | S100 calcium binding protein A3 | |||||
Macaque | S100 calcium binding protein A3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | S100 calcium binding protein A3 | |||||
Publication Statistics
PubMed Score 32.15
PubMed score by year
PubTator Score 26.63
PubTator score by year
Related Publications
Text Mined References (22)
GeneRif Annotations (8)
Items per page:
0 of 0
PMID | Year | Title |
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