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Tbio
S100A3
Protein S100-A3

Protein Summary
Description
Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has the highest content of cysteines of all S100 proteins, has a high affinity for Zinc, and is highly expressed in human hair cuticle. The precise function of this protein is unknown. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368712
  • ENSP00000357701
  • ENSG00000188015
  • ENST00000368713
  • ENSP00000357702

Symbol
  • S100E
  • S100E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.95
virus perturbation
0.76
protein domain
0.58
tissue sample
0.54
small molecule perturbation
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.15   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 194   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.15   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
FBXL4
Tbio
Novelty:  0.04286856
p_int:  0.999967025
p_ni:  0.00003297
p_wrong:  5e-9
Data Source:  BioPlex
TFG
Tbio
Novelty:  0.00320616
p_int:  0.999636392
p_ni:  0.000363424
p_wrong:  1.84e-7
Score:  0.179
Data Source:  BioPlex,STRINGDB
MRPL38
Tdark
Novelty:  0.71587283
p_int:  0.999547133
p_ni:  0.000452746
p_wrong:  1.21e-7
Data Source:  BioPlex
ELOA2
Tdark
Family:  Enzyme
Novelty:  0.7420148
p_int:  0.998634297
p_ni:  0.000931791
p_wrong:  0.000433912
Data Source:  BioPlex
BTC
Tbio
Novelty:  0.00673076
p_int:  0.997901357
p_ni:  0.00093788
p_wrong:  0.001160762
Data Source:  BioPlex
PYHIN1
Tbio
Novelty:  0.06662677
p_int:  0.996688516
p_ni:  0.001677663
p_wrong:  0.001633821
Score:  0.185
Data Source:  BioPlex,STRINGDB
FBXO3
Tbio
Novelty:  0.01701102
p_int:  0.995343336
p_ni:  0.000087026
p_wrong:  0.004569638
Data Source:  BioPlex
IL31RA
Tbio
Novelty:  0.00737445
p_int:  0.994606218
p_ni:  0.000539151
p_wrong:  0.004854631
Score:  0.302
Data Source:  BioPlex,STRINGDB
ZMAT4
Tdark
Novelty:  0.31281969
p_int:  0.992951769
p_ni:  0.000406677
p_wrong:  0.006641553
Data Source:  BioPlex
OR51E2
Tchem
Family:  oGPCR
Novelty:  0.02435259
p_int:  0.991591764
p_ni:  0.000357072
p_wrong:  0.008051164
Score:  0.189
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
24.4
high density lipoprotein cholesterol measurement
1
1
1
6.9
sleep duration
1
1
1
6.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
24.4
high density lipoprotein cholesterol measurement
1
6.9
sleep duration
1
6.9
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
S100 calcium binding protein A3
VGNC:1525
100614295
Macaque
S100 calcium binding protein A3
100426715
Mouse
MGI:1338849
20197
Rat
RGD:620260
114216
Dog
S100 calcium binding protein A3
VGNC:45829
490460
Species
Name
OMA
EggNOG
Inparanoid
Chimp
S100 calcium binding protein A3
Macaque
S100 calcium binding protein A3
Mouse
Rat
Dog
S100 calcium binding protein A3
Publication Statistics
PubMed Score 32.15
PubMed score by year
PubTator Score 26.63
PubTator score by year
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Related Publications
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PMID
Year
Title