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Tbio
S100A13
Protein S100-A13

Protein Summary
Description
Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity). The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a high expression level in thyroid gland. In smooth muscle cell ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339556
  • ENSP00000344822
  • ENSG00000189171
  • ENST00000392622
  • ENSP00000376398
  • ENST00000392623
  • ENSP00000376399
  • ENST00000440685
  • ENSP00000392767
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
PubMedID
0.88
kinase perturbation
0.84
transcription factor perturbation
0.84
transcription factor binding site profile
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.49   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.49   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
SNRNP27
Tbio
Novelty:  0.0175187
p_int:  0.96474326
p_ni:  0.031627444
p_wrong:  0.003629296
Score:  0.248
Data Source:  BioPlex,STRINGDB
MGST3
Tbio
Family:  Enzyme
Novelty:  0.02891864
p_int:  0.96474326
p_ni:  0.031627444
p_wrong:  0.003629296
Score:  0.187
Data Source:  BioPlex,STRINGDB
SPRY2
Tbio
Novelty:  0.00884945
p_int:  0.95423145
p_ni:  0.041195312
p_wrong:  0.004573238
Score:  0.252
Data Source:  BioPlex,STRINGDB
SDC2
Tbio
Novelty:  0.00597758
p_int:  0.950911363
p_ni:  0.049080234
p_wrong:  0.000008404
Score:  0.167
Data Source:  BioPlex,STRINGDB
KIFAP3
Tbio
Novelty:  0.01902437
p_int:  0.940176867
p_ni:  0.059811413
p_wrong:  0.00001172
Data Source:  BioPlex
CCL5
Tchem
Novelty:  0.00032607
p_int:  0.770910481
p_ni:  0.229083869
p_wrong:  0.00000565
Score:  0.235
Data Source:  BioPlex,STRINGDB
FGF1
Tchem
Novelty:  0.00055979
Score:  0.968
Data Source:  STRINGDB
SYT1
Tbio
Novelty:  0.00176103
Score:  0.956
Data Source:  STRINGDB
IL1A
Tchem
Novelty:  0.00019366
Score:  0.929
Data Source:  STRINGDB
AGER
Tchem
Novelty:  0.00061101
Score:  0.864
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
2
2
2
62.5
blood protein measurement
2
1
2
55.6
mean arterial pressure
1
1
1
49.3
monocyte count
2
2
2
47.1
diastolic blood pressure
1
1
1
42.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
2
62.5
blood protein measurement
2
55.6
mean arterial pressure
1
49.3
monocyte count
2
47.1
diastolic blood pressure
1
42.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
S100 calcium binding protein A13
VGNC:1526
457324
Mouse
MGI:109581
20196
Rat
RGD:1304919
295213
Dog
S100 calcium binding protein A13
VGNC:45825
490457
Horse
S100 calcium binding protein A13
VGNC:22649
100056308
Species
Name
OMA
EggNOG
Inparanoid
Chimp
S100 calcium binding protein A13
Mouse
Rat
Dog
S100 calcium binding protein A13
Horse
S100 calcium binding protein A13
Publication Statistics
PubMed Score 40.49
PubMed score by year
PubTator Score 31.99
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title