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Tbio
S100A12
Protein S100-A12

Protein Summary
Description
S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368737
  • ENSP00000357726
  • ENSG00000163221

Symbol
  • p6
  • CAGC
  • CGRP
  • MRP6
  • CAAF1
  • MRP-6
  • ENRAGE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.89
pathway
0.86
biological term
0.72
tissue sample
0.64
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 453.69   (req: < 5)
Gene RIFs: 98   (req: <= 3)
Antibodies: 308   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 453.69   (req: >= 5)
Gene RIFs: 98   (req: > 3)
Antibodies: 308   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (110)
AGER
Tchem
Novelty:  0.00061101
Score:  0.991
Data Source:  STRINGDB
S100A8
Tbio
Novelty:  0.00107914
Score:  0.985
Data Source:  STRINGDB
HMGB1
Tchem
Family:  TF
Novelty:  0.00043845
Score:  0.955
Data Source:  STRINGDB
SAA1
Tbio
Novelty:  0.0006102
Score:  0.942
Data Source:  STRINGDB
S100A9
Tchem
Novelty:  0.00185141
Score:  0.931
Data Source:  STRINGDB
NFKB1
Tclin
Family:  TF
Novelty:  0.00198195
Score:  0.922
Data Source:  STRINGDB
MAPK3
Tchem
Family:  Kinase
Novelty:  0.00012969
Score:  0.916
Data Source:  STRINGDB
MAPK1
Tchem
Family:  Kinase
Novelty:  0.00061058
Score:  0.912
Data Source:  STRINGDB
APP
Tchem
Novelty:  0.00008964
Score:  0.911
Data Source:  STRINGDB
RELA
Tchem
Family:  TF
Novelty:  0.0007137
Score:  0.908
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (27)
Advanced glycosylation endproduct receptor signaling (R-HSA-879415)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 27
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Advanced glycosylation endproduct receptor signaling
Reactome
Cytokine Signaling in Immune system
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Advanced glycosylation endproduct receptor signaling
Cytokine Signaling in Immune system
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
1
1
1
38.2
monocyte percentage of leukocytes
2
1
2
34.8
monocyte count
1
1
1
28
basophil percentage of leukocytes
1
1
1
17
matrix metalloproteinase 8 measurement
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
1
38.2
monocyte percentage of leukocytes
2
34.8
monocyte count
1
28
basophil percentage of leukocytes
1
17
matrix metalloproteinase 8 measurement
1
14.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
S100 calcium binding protein A12
VGNC:1524
469835
Dog
S100 calcium binding protein A12
VGNC:45824
100683919
Horse
S100 calcium binding protein A12
VGNC:22648
100056061
Cow
S100 calcium binding protein A12
282467
Species
Name
OMA
EggNOG
Inparanoid
Chimp
S100 calcium binding protein A12
Dog
S100 calcium binding protein A12
Horse
S100 calcium binding protein A12
Cow
S100 calcium binding protein A12
Publication Statistics
PubMed Score 453.69
PubMed score by year
PubTator Score 365.06
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title