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Tbio
S100A10
Protein S100-A10

Protein Summary
Description
Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in exocytosis and endocytosis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368809
  • ENSP00000357799
  • ENSG00000197747
  • ENST00000368811
  • ENSP00000357801

Symbol
  • ANX2LG
  • CAL1L
  • CLP11
  • 42C
  • P11
  • p10
  • GP11
  • ANX2L
  • CAL1L
  • CLP11
  • Ca[1]
  • ANX2LG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
disease perturbation
0.97
kinase perturbation
0.97
gene perturbation
0.85
PubMedID
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 360.42   (req: < 5)
Gene RIFs: 67   (req: <= 3)
Antibodies: 465   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 360.42   (req: >= 5)
Gene RIFs: 67   (req: > 3)
Antibodies: 465   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (93)
ANXA2
Tbio
Novelty:  0.00103362
p_int:  0.999958471
p_ni:  0.000041529
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
TAB1
Tchem
Family:  Kinase
Novelty:  0.00721424
p_int:  0.995348792
p_ni:  0.004651208
Data Source:  BioPlex
TNFRSF10A
Tchem
Novelty:  0.0003383
p_int:  0.9202891
p_ni:  0.0797109
Data Source:  BioPlex
UQCRB
Tbio
Novelty:  0.02933046
p_int:  0.900168657
p_ni:  0.098876417
p_wrong:  0.000954926
Score:  0.228
Data Source:  BioPlex,STRINGDB
AHNAK
Tbio
Novelty:  0.01201996
Score:  0.992
Data Source:  STRINGDB
HLTF
Tbio
Family:  Enzyme
Novelty:  0.01177896
Score:  0.985
Data Source:  STRINGDB
PLG
Tclin
Family:  Enzyme
Novelty:  0.00004806
Score:  0.972
Data Source:  STRINGDB
PLAT
Tclin
Family:  Enzyme
Novelty:  0.00017503
Score:  0.961
Data Source:  STRINGDB
CAVIN1
Tbio
Family:  Enzyme
Novelty:  0.00780634
Score:  0.946
Data Source:  STRINGDB
FHL2
Tbio
Novelty:  0.00501273
Score:  0.944
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Dissolution of Fibrin Clot (R-HSA-75205)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Dissolution of Fibrin Clot
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Dissolution of Fibrin Clot
Hemostasis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
3
3
3
91.9
vitamin D measurement
3
2
3
86.2
3
2
2
1.1
84.9
2
2
0
1.2
74.1
serum metabolite measurement
2
2
2
62.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
3
91.9
vitamin D measurement
3
86.2
2
1.1
84.9
0
1.2
74.1
serum metabolite measurement
2
62.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
S100 calcium binding protein A10
VGNC:1522
457306
Mouse
MGI:1339468
20194
Rat
RGD:628655
81778
Dog
S100 calcium binding protein A10
475851
Horse
S100 calcium binding protein A10
VGNC:22646
100034012
Species
Name
OMA
EggNOG
Inparanoid
Chimp
S100 calcium binding protein A10
Mouse
Rat
Dog
S100 calcium binding protein A10
Horse
S100 calcium binding protein A10
Publication Statistics
PubMed Score 360.42
PubMed score by year
PubTator Score 1020.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title