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Tclin
RYR1
Ryanodine receptor 1

Protein Summary
Description
Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed:11741831, PubMed:16163667). Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (PubMed:18268335). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity). This gene encodes a ryanodine receptor found in skeletal muscle. The encoded protein functions as a calcium release channel in the sarcoplasmic reticulum but also serves to connect the sarcoplasmic reticulum and transverse tubule. Mutations in this gene are associated with malign ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355481
  • ENSP00000347667
  • ENSG00000196218
  • ENST00000359596
  • ENSP00000352608

Symbol
  • RYDR
  • CCO
  • MHS
  • RYR
  • MHS1
  • RYDR
  • SKRR
  • RYR-1
  • PPP1R137
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.96
cellular component
0.91
gene perturbation
0.91
phenotype
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1400.79   (req: < 5)
Gene RIFs: 185   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1400.79   (req: >= 5)
Gene RIFs: 185   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (199)
FKBP1B
Tchem
Family:  Enzyme
Novelty:  0.00541222
Score:  0.992
Data Source:  STRINGDB
TRDN
Tbio
Novelty:  0.00501554
Score:  0.99
Data Source:  STRINGDB
CACNA1S
Tclin
Family:  IC
Novelty:  0.00434282
Score:  0.987
Data Source:  STRINGDB
FKBP1A
Tclin
Family:  Enzyme
Novelty:  0.00116174
Score:  0.985
Data Source:  STRINGDB
CALM1
Tclin
Novelty:  0.00308267
Score:  0.974
Data Source:  STRINGDB
ASPH
Tbio
Family:  Enzyme
Novelty:  0.00291455
Score:  0.966
Data Source:  STRINGDB
NOS1
Tchem
Family:  Enzyme
Novelty:  0.00032064
Score:  0.919
Data Source:  STRINGDB
CACNA1C
Tclin
Family:  IC
Novelty:  0.00099998
Score:  0.919
Data Source:  STRINGDB
STAC3
Tbio
Novelty:  0.03431498
Score:  0.903
Data Source:  STRINGDB
CACNA1A
Tchem
Family:  IC
Novelty:  0.00069217
Score:  0.897
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Ion channel transport
Reactome
Ion homeostasis
Reactome
Muscle contraction
Reactome
Stimuli-sensing channels
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Ion channel transport
Ion homeostasis
Muscle contraction
Stimuli-sensing channels
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (44)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CACAO
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
3
3
4
94.8
basophil percentage of leukocytes
2
3
3
94.5
mean platelet volume
2
2
2
89.8
eosinophil count
3
2
4
82.4
basophil percentage of granulocytes
1
1
1
66.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
4
94.8
basophil percentage of leukocytes
3
94.5
mean platelet volume
2
89.8
eosinophil count
4
82.4
basophil percentage of granulocytes
1
66.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ryanodine receptor 1
VGNC:7491
100612063
Mouse
MGI:99659
20190
Rat
RGD:1586637
114207
Dog
ryanodine receptor 1
VGNC:45821
606491
Horse
ryanodine receptor 1
VGNC:51076
100034090
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ryanodine receptor 1
Mouse
Rat
Dog
ryanodine receptor 1
Horse
ryanodine receptor 1
Publication Statistics
PubMed Score 1400.79
PubMed score by year
PubTator Score 1118.62
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title