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Tbio
RYK
Tyrosine-protein kinase RYK

Protein Summary
Description
May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development. The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000620660
  • ENSP00000478721
  • ENSG00000163785
  • ENST00000623711
  • ENSP00000485095

Symbol
  • JTK5A
  • JTK5
  • RYK1
  • JTK5A
  • D3S3195
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
disease perturbation
0.9
protein domain
0.85
kinase perturbation
0.81
transcription factor perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.17   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.17   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (106)
CEACAM21
Tdark
Novelty:  0.46116153
p_int:  0.999997456
p_ni:  0.000002495
p_wrong:  4.9e-8
Data Source:  BioPlex
NCR3LG1
Tbio
Novelty:  0.02681936
p_int:  0.999978944
p_ni:  0.000021056
Score:  0.222
Data Source:  BioPlex,STRINGDB
SLC39A5
Tbio
Family:  Transporter
Novelty:  0.05205571
p_int:  0.999939867
p_ni:  0.000046687
p_wrong:  0.000013447
Data Source:  BioPlex
TNFSF8
Tbio
Novelty:  0.01292216
p_int:  0.999911726
p_ni:  0.000088203
p_wrong:  7.1e-8
Data Source:  BioPlex
PVR
Tbio
Novelty:  0.00215811
p_int:  0.999801544
p_ni:  0.000083559
p_wrong:  0.000114897
Data Source:  BioPlex
RAET1E
Tbio
Novelty:  0.01859274
p_int:  0.999385976
p_ni:  0.000612018
p_wrong:  0.000002006
Score:  0.392
Data Source:  BioPlex,STRINGDB
MILR1
Tbio
Novelty:  0.07477675
p_int:  0.999200401
p_ni:  0.000174654
p_wrong:  0.000624945
Score:  0.188
Data Source:  BioPlex,STRINGDB
SIGLECL1
Tdark
p_int:  0.9989624
p_ni:  0.000168178
p_wrong:  0.000869421
Data Source:  BioPlex
MICA
Tbio
Novelty:  0.03965901
p_int:  0.993014985
p_ni:  0.005405099
p_wrong:  0.001579916
Score:  0.213
Data Source:  BioPlex,STRINGDB
CDH5
Tbio
Novelty:  0.00072649
p_int:  0.834074022
p_ni:  0.00045073
p_wrong:  0.165475247
Score:  0.172
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (342)
Beta-catenin independent WNT signaling (R-HSA-3858494)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-catenin independent WNT signaling
Reactome
PCP/CE pathway
Reactome
Signal Transduction
Reactome
Signaling by WNT
Reactome
TCF dependent signaling in response to WNT
Name
Explore in Pharos
Explore in Source
Beta-catenin independent WNT signaling
PCP/CE pathway
Signal Transduction
Signaling by WNT
TCF dependent signaling in response to WNT
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (38)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Traceable Author Statement (TAS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.1
77.1
body height
1
1
1
65.9
testosterone measurement
1
1
1
46.5
1
1
0
1.1
30.2
ferritin measurement
1
1
1
27.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
77.1
body height
1
65.9
testosterone measurement
1
46.5
0
1.1
30.2
ferritin measurement
1
27.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
receptor-like tyrosine kinase
718950
Mouse
MGI:101766
20187
Rat
RGD:620549
140585
Dog
receptor-like tyrosine kinase
VGNC:45820
477074
Horse
receptor-like tyrosine kinase
VGNC:22642
100065602
Species
Name
OMA
EggNOG
Inparanoid
Macaque
receptor-like tyrosine kinase
Mouse
Rat
Dog
receptor-like tyrosine kinase
Horse
receptor-like tyrosine kinase
Publication Statistics
PubMed Score 114.17
PubMed score by year
PubTator Score 42.00
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title