You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RYBP
RING1 and YY1-binding protein

Protein Summary
Description
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (By similarity). Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (PubMed:19098711). May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis ( ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000477973
  • ENSP00000419494
  • ENSG00000163602

Symbol
  • DEDAF
  • YEAF1
  • AAP1
  • DEDAF
  • YEAF1
  • APAP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
hub protein
0.95
PubMedID
0.87
transcription factor binding site profile
0.86
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.15   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 423   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.15   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 423   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
PCGF2
Tbio
Novelty:  0.02148755
p_int:  1
Score:  0.988
Data Source:  BioPlex,Reactome,STRINGDB
PCGF6
Tbio
Novelty:  0.07032909
p_int:  1
Score:  0.91
Data Source:  BioPlex,Reactome,STRINGDB
PCGF1
Tbio
Novelty:  0.06481661
p_int:  0.999999985
p_ni:  1e-8
p_wrong:  5e-9
Score:  0.927
Data Source:  BioPlex,STRINGDB
PCGF3
Tbio
Novelty:  0.14226976
p_int:  0.999999958
p_ni:  4.2e-8
Score:  0.904
Data Source:  BioPlex,STRINGDB
L3MBTL2
Tbio
Family:  Epigenetic
Novelty:  0.11193867
p_int:  0.999999909
p_ni:  9.1e-8
Score:  0.91
Data Source:  BioPlex,Reactome,STRINGDB
KDM2B
Tchem
Family:  Epigenetic
Novelty:  0.01630517
p_int:  0.999999868
p_ni:  7.5e-8
p_wrong:  5.7e-8
Score:  0.927
Data Source:  BioPlex,STRINGDB
PCGF5
Tdark
Novelty:  0.11370936
p_int:  0.999999815
p_ni:  1.85e-7
Score:  0.993
Data Source:  BioPlex,STRINGDB
BMI1
Tbio
Novelty:  0.00158043
p_int:  0.999999731
p_ni:  2.69e-7
Score:  0.774
Data Source:  BioPlex,Reactome,STRINGDB
MORC4
Tbio
Novelty:  0.17017364
p_int:  0.999999492
p_ni:  4.99e-7
p_wrong:  9e-9
Score:  0.795
Data Source:  BioPlex,STRINGDB
FBRS
Tbio
Novelty:  0.13646817
p_int:  0.999999351
p_ni:  6.49e-7
Score:  0.84
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Reactome
Transcriptional Regulation by E2F6
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Transcriptional Regulation by E2F6
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
4
4
4
95.4
BMI-adjusted hip circumference
2
8
9
72.7
monocyte count
3
2
3
66.4
BMI-adjusted waist circumference
4
4
5
63.1
self reported educational attainment
2
2
1
6.1
61
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
4
95.4
BMI-adjusted hip circumference
9
72.7
monocyte count
3
66.4
BMI-adjusted waist circumference
5
63.1
self reported educational attainment
1
6.1
61
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1929059
56353
Rat
RGD:1307077
312603
Dog
RING1 and YY1 binding protein [Source:HGNC Symbol;Acc:HGNC:10480]
Horse
RING1 and YY1 binding protein [Source:HGNC Symbol;Acc:HGNC:10480]
Opossum
RING1 and YY1 binding protein [Source:HGNC Symbol;Acc:HGNC:10480]
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
RING1 and YY1 binding protein [Source:HGNC Symbol;Acc:HGNC:10480]
Horse
RING1 and YY1 binding protein [Source:HGNC Symbol;Acc:HGNC:10480]
Opossum
RING1 and YY1 binding protein [Source:HGNC Symbol;Acc:HGNC:10480]
Publication Statistics
PubMed Score 115.15
PubMed score by year
PubTator Score 37.89
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title