Tclin RXRG Retinoic acid receptor RXR-gamma

Protein Summary

Description

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity). This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]

Uniprot Accession IDs

• P48443
• A6NIP1
• Q6IBU7

Gene Name

• RXRG

Ensembl ID

• ENST00000359842
• ENSP00000352900
• ENSG00000143171

Symbol

• NR2B3
• RXRC
• NR2B3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	1
gene perturbation	0.97
molecular function	0.94
protein domain	0.92
biological process	0.79

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Retinoic Acid Receptor Rxr-gamma

Protein / Receptor / Retinoic Acid Receptor Rxr-gamma

Protein / Nucleic Acid Binding / Retinoic Acid Receptor Rxr-gamma

Protein / ... / C4 Zinc Finger Nuclear Receptor / Retinoic Acid Receptor Rxr-gamma

DTO Classes

Protein / Nuclear Receptor / Retinoid X Receptors / Retinoic Acid Receptor Rxr-gamma

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.17   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 368   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.17   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 368   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 69

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4