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Tchem
RXFP3
Relaxin-3 receptor 1

Protein Summary
Description
Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330120
  • ENSP00000328708
  • ENSG00000182631
  • ENST00000616205
  • ENSP00000480733
  • ENSG00000277069

Symbol
  • RLN3R1
  • SALPR
  • SALPR
  • RLN3R1
  • RXFPR3
  • GPCR135
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.65
cell line
0.64
tissue
0.6
histone modification site profile
0.51
virus perturbation
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.8   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 247   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.8   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 247   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (245)
RLN3
Tbio
Novelty:  0.0107593
Score:  0.996
Data Source:  Reactome,STRINGDB
INSL5
Tbio
Novelty:  0.04351334
Score:  0.985
Data Source:  STRINGDB
RXFP1
Tchem
Family:  GPCR
Novelty:  0.00580827
Score:  0.985
Data Source:  STRINGDB
RXFP2
Tbio
Family:  GPCR
Novelty:  0.00932189
Score:  0.969
Data Source:  STRINGDB
DRD4
Tchem
Family:  GPCR
Novelty:  0.00099622
Score:  0.944
Data Source:  STRINGDB
SST
Tbio
Novelty:  0.00005944
Score:  0.939
Data Source:  STRINGDB
TAS2R13
Tchem
Family:  GPCR
Novelty:  0.25394315
Score:  0.923
Data Source:  STRINGDB
GPR37L1
Tbio
Family:  GPCR
Novelty:  0.08467087
Score:  0.922
Data Source:  STRINGDB
GNG4
Tbio
Novelty:  0.14371438
Score:  0.92
Data Source:  STRINGDB
GAL
Tbio
Novelty:  0.0005132
Score:  0.918
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (32)
Items per page:
1 – 5 of 32
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
4
5
2
3.3
99.7
hair color
4
5
2
3.3
99.7
hair colour measurement
3
3
4
98.7
hair colour measurement
3
3
4
98.7
suntan
2
2
2
98.4
Items per page:
1 – 5 of 32
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
2
3.3
99.7
hair color
2
3.3
99.7
hair colour measurement
4
98.7
hair colour measurement
4
98.7
suntan
2
98.4
Find similar targets by:
IDG Resources
Genetic Construct
RXFP3-Tango
image for RXFP3-Tango
Details:
  • Vector:  addgene66494
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • RXFP3-Tango
Order Genetic Construct from:
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
relaxin family peptide receptor 3
VGNC:14162
471583
Mouse
MGI:2441827
239336
Rat
RGD:1311550
294807
Opossum
relaxin/insulin like family peptide receptor 3 [Source:HGNC Symbol;Acc:HGNC:24883]
Platypus
relaxin/insulin like family peptide receptor 3
100088566
Species
Name
OMA
EggNOG
Inparanoid
Chimp
relaxin family peptide receptor 3
Mouse
Rat
Opossum
relaxin/insulin like family peptide receptor 3 [Source:HGNC Symbol;Acc:HGNC:24883]
Platypus
relaxin/insulin like family peptide receptor 3
Publication Statistics
PubMed Score 74.80
PubMed score by year
PubTator Score 44.46
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title