You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
RXFP1
Relaxin receptor 1

Protein Summary
Description
Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP. This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307765
  • ENSP00000303248
  • ENSG00000171509
  • ENST00000343542
  • ENSP00000345889
  • ENST00000470033
  • ENSP00000420712
  • ENST00000471616
  • ENSP00000434475

Symbol
  • LGR7
  • LGR7
  • RXFPR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
ligand (protein)
0.68
biological term
0.64
cell type or tissue
0.59
cell line
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 213.61   (req: < 5)
Gene RIFs: 56   (req: <= 3)
Antibodies: 334   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 213.61   (req: >= 5)
Gene RIFs: 56   (req: > 3)
Antibodies: 334   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (234)
CNPY4
Tdark
Novelty:  0.59578334
p_int:  0.999999778
p_ni:  2.22e-7
Data Source:  BioPlex
LRRC8D
Tbio
Novelty:  0.10536285
p_int:  0.999974079
p_ni:  0.000025916
p_wrong:  5e-9
Data Source:  BioPlex
TMEM237
Tdark
Novelty:  0.27005874
p_int:  0.999972831
p_ni:  0.00000492
p_wrong:  0.000022249
Data Source:  BioPlex
ABHD6
Tchem
Family:  Enzyme
Novelty:  0.019314
p_int:  0.99994319
p_ni:  0.000055909
p_wrong:  9.01e-7
Data Source:  BioPlex
SLC12A4
Tbio
Family:  Transporter
Novelty:  0.01077688
p_int:  0.999857745
p_ni:  0.000142253
p_wrong:  2e-9
Data Source:  BioPlex
CGRRF1
Tdark
Novelty:  0.49690187
p_int:  0.999793277
p_ni:  0.000206621
p_wrong:  1.02e-7
Data Source:  BioPlex
ABCC5
Tchem
Family:  Transporter
Novelty:  0.00566605
p_int:  0.999756599
p_ni:  0.000022015
p_wrong:  0.000221386
Data Source:  BioPlex
PPM1L
Tbio
Family:  Enzyme
Novelty:  0.09146774
p_int:  0.999511041
p_ni:  0.000288257
p_wrong:  0.000200703
Data Source:  BioPlex
DNAJC18
Tdark
Novelty:  1.38573997
p_int:  0.999378223
p_ni:  0.000621777
Data Source:  BioPlex
KCNT2
Tchem
Family:  IC
Novelty:  0.02412039
p_int:  0.999179563
p_ni:  0.000819571
p_wrong:  8.66e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (38)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
3
2
6
93.5
metabolite measurement
3
2
3
87.7
acylcarnitine measurement
1
1
2
70.2
serum metabolite measurement
1
1
2
54.4
1
1
1
2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
6
93.5
metabolite measurement
3
87.7
acylcarnitine measurement
2
70.2
serum metabolite measurement
2
54.4
1
2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
relaxin/insulin like family peptide receptor 1
461572
Macaque
relaxin/insulin like family peptide receptor 1
701107
Mouse
MGI:2682211
381489
Rat
RGD:1302973
295144
Dog
relaxin family peptide receptor 1
VGNC:54222
100855494
Species
Name
OMA
EggNOG
Inparanoid
Chimp
relaxin/insulin like family peptide receptor 1
Macaque
relaxin/insulin like family peptide receptor 1
Mouse
Rat
Dog
relaxin family peptide receptor 1
Publication Statistics
PubMed Score 213.61
PubMed score by year
PubTator Score 136.40
PubTator score by year
Patents
Patents by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title