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Tdark
RWDD2B
RWD domain-containing protein 2B

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000493196
  • ENSP00000418693
  • ENSG00000156253

Symbol
  • C21orf6
  • GL011
  • C21orf6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
cell type or tissue
0.67
tissue sample
0.67
histone modification site profile
0.59
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.54   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 12   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.54   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 12   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
ATF6B
Tbio
Family:  TF
Novelty:  0.07061573
p_int:  0.999997818
p_ni:  0.000002182
Score:  0.169
Data Source:  BioPlex,STRINGDB
MYH11
Tbio
Novelty:  0.00142474
p_int:  0.999996185
p_ni:  0.000003809
p_wrong:  6e-9
Score:  0.214
Data Source:  BioPlex,STRINGDB
PDLIM5
Tbio
Novelty:  0.0040646
p_int:  0.99993842
p_ni:  0.00006158
Score:  0.795
Data Source:  BioPlex,STRINGDB
DCAF5
Tdark
Novelty:  0.39565074
p_int:  0.99976461
p_ni:  0.00023539
Data Source:  BioPlex
NRGN
Tbio
Novelty:  0.00352757
p_int:  0.998822309
p_ni:  0.001139677
p_wrong:  0.000038014
Score:  0.239
Data Source:  BioPlex,STRINGDB
GOLPH3L
Tbio
Novelty:  0.30373124
p_int:  0.984995709
p_ni:  0.010704762
p_wrong:  0.004299529
Score:  0.21
Data Source:  BioPlex,STRINGDB
PLS1
Tbio
Novelty:  0.00538817
p_int:  0.971298097
p_ni:  0.028701903
Data Source:  BioPlex
ARMT1
Tbio
Family:  Enzyme
Novelty:  0.19632869
p_int:  0.903995525
p_ni:  0.096000998
p_wrong:  0.000003477
Score:  0.188
Data Source:  BioPlex,STRINGDB
DENR
Tbio
Novelty:  0.00653432
p_int:  0.834064758
p_ni:  0.03720225
p_wrong:  0.128732991
Score:  0.234
Data Source:  BioPlex,STRINGDB
UBN2
Tbio
Novelty:  0.09777456
Score:  0.737
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
1
3
80.9
reticulocyte count
2
1
2
80.2
serum gamma-glutamyl transferase measurement
2
2
2
75.4
electrocardiography
1
1
3
27.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
80.9
reticulocyte count
2
80.2
serum gamma-glutamyl transferase measurement
2
75.4
electrocardiography
3
27.3
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RWD domain containing 2B
VGNC:1126
473941
Macaque
RWD domain containing 2B
706524
Mouse
MGI:1858215
53858
Rat
RGD:1305062
304132
Dog
RWD domain containing 2B
VGNC:45815
487716
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RWD domain containing 2B
Macaque
RWD domain containing 2B
Mouse
Rat
Dog
RWD domain containing 2B
Publication Statistics
PubMed Score 2.54
PubMed score by year
PubTator Score 1.00
PubTator score by year
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Related Publications
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PMID
Year
Title