Tbio RUNX3 Runt-related transcription factor 3

Protein Summary

Description

Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Uniprot Accession IDs

• Q13761
• B1AJV5
• Q12969
• Q13760

Gene Name

• RUNX3

Ensembl ID

• ENST00000308873
• ENSP00000308051
• ENSG00000020633
• ENST00000338888
• ENSP00000343477
• ENST00000399916
• ENSP00000382800

Symbol

• AML2
• CBFA3
• PEBP2A3
• AML2
• CBFA3
• PEBP2aC

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
protein domain	0.92
biological process	0.86
hub protein	0.85
kinase perturbation	0.84

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Runt-related Transcription Factor 3

Protein / Nucleic Acid Binding / Runt-related Transcription Factor 3

Protein / ... / Runt Transcription Factor / Runt-related Transcription Factor 3

DTO Classes

Protein / Transcription Factor / Immunoglobulin Fold Transcription Factor / Runt Transcription Factor / Runt-related Transcription Factor 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 832.45   (req: < 5)

Gene RIFs: 381   (req: <= 3)

Antibodies: 627   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 832.45   (req: >= 5)

Gene RIFs: 381   (req: > 3)

Antibodies: 627   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0