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Tbio
RUNX1T1
Protein CBFA2T1

Protein Summary
Description
Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Can repress transactivation mediated by TCF12 (PubMed:16803958). Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal (PubMed:23812588). This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265814
  • ENSP00000265814
  • ENSG00000079102
  • ENST00000360348
  • ENSP00000353504
  • ENST00000396218
  • ENSP00000379520
  • ENST00000422361
  • ENSP00000390137
  • ENST00000518844
  • ENSP00000430728
  • ENST00000520724
  • ENSP00000428742
  • ENST00000523629
  • ENSP00000428543
  • ENST00000613302
  • ENSP00000481799
  • ENST00000613886
  • ENSP00000478331
  • ENST00000614812
  • ENSP00000481315
  • ENST00000617740
  • ENSP00000481112

Symbol
  • AML1T1
  • CBFA2T1
  • CDR
  • ETO
  • MTG8
  • ZMYND2
  • CDR
  • ETO
  • MTG8
  • AML1T1
  • ZMYND2
  • CBFA2T1
  • AML1-MTG8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.91
transcription factor
0.84
biological term
0.83
kinase perturbation
0.76
disease perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 428.85   (req: < 5)
Gene RIFs: 104   (req: <= 3)
Antibodies: 256   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 428.85   (req: >= 5)
Gene RIFs: 104   (req: > 3)
Antibodies: 256   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0