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Tbio
RUNX1
Runt-related transcription factor 1

Protein Summary
Description
Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis (PubMed:17431401). Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter (PubMed:10207087, PubMed:14970218). Inhibits KAT6B-dependent transcriptional activation (By similarity). Involved in lineage commitment of immature T cell precursors. CBF complexes repress ZB ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.99
molecular function
0.99
PubMedID
0.98
transcription factor perturbation
0.98
biological process
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.48   (req: < 5)
Gene RIFs: 544   (req: <= 3)
Antibodies: 1012   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.48   (req: >= 5)
Gene RIFs: 544   (req: > 3)
Antibodies: 1012   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (252)
CBFB
Tchem
Family:  TF
Novelty:  0.04825679
p_int:  0.999999983
p_ni:  1.6e-8
p_wrong:  1e-9
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
CEBPA
Tbio
Family:  TF
Novelty:  0.00056459
Score:  0.98
Data Source:  STRINGDB
SPI1
Tbio
Family:  TF
Novelty:  0.00064309
Score:  0.978
Data Source:  STRINGDB
ETS1
Tbio
Family:  TF
Novelty:  0.00105233
Score:  0.974
Data Source:  STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
Score:  0.969
Data Source:  Reactome,STRINGDB
FOXP3
Tbio
Family:  TF
Novelty:  0.00017205
Score:  0.969
Data Source:  Reactome,STRINGDB
GATA1
Tbio
Family:  TF
Novelty:  0.00077901
Score:  0.968
Data Source:  STRINGDB
GATA2
Tbio
Family:  TF
Novelty:  0.00153967
Score:  0.968
Data Source:  STRINGDB
TAL1
Tbio
Family:  TF
Novelty:  0.00294416
Score:  0.967
Data Source:  STRINGDB
MYB
Tbio
Family:  TF
Novelty:  0.00092053
Score:  0.967
Data Source:  Reactome,STRINGDB
Pathways (48)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 35
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent gene expression
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Developmental Biology
ESR-mediated signaling
Estrogen-dependent gene expression
Gene expression (Transcription)
Generic Transcription Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (42)
Find Similar Targets
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (52)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
11
13
99.6
eosinophil percentage of leukocytes
2
9
10
99.3
eosinophil percentage of granulocytes
1
4
4
97
balding measurement
2
3
3
96.7
sum of eosinophil and basophil counts
1
4
4
96.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
13
99.6
eosinophil percentage of leukocytes
10
99.3
eosinophil percentage of granulocytes
4
97
balding measurement
3
96.7
sum of eosinophil and basophil counts
4
96.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
runt related transcription factor 1
101058316
Macaque
runt related transcription factor 1
696749
Mouse
MGI:99852
12394
Rat
RGD:2283
50662
Dog
runt related transcription factor 1
VGNC:49641
487746
Species
Name
OMA
EggNOG
Inparanoid
Chimp
runt related transcription factor 1
Macaque
runt related transcription factor 1
Mouse
Rat
Dog
runt related transcription factor 1
Publication Statistics
PubMed Score 136.48
PubMed score by year
PubTator Score 1500.14
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title