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Tdark
RUNDC3A
RUN domain-containing protein 3A

Protein Summary
Description
May act as an effector of RAP2A in neuronal cells.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225441
  • ENSP00000225441
  • ENSG00000108309
  • ENST00000426726
  • ENSP00000410862
  • ENST00000590941
  • ENSP00000468214

Symbol
  • RAP2IP
  • RPIP8
  • RPIP8
  • RAP2IP
  • RPIP-8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.69
transcription factor
0.69
disease perturbation
0.68
PubMedID
0.58
transcription factor binding site profile
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.86   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 176   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.86   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
RUNDC3B
Tbio
Novelty:  0.12462899
p_int:  0.999999706
p_wrong:  2.94e-7
Score:  0.353
Data Source:  BioPlex,STRINGDB
CCDC186
Tdark
Novelty:  0.44973807
p_int:  0.999999492
p_ni:  5.08e-7
Score:  0.213
Data Source:  BioPlex,STRINGDB
EPS15
Tchem
Novelty:  0.00451447
p_int:  0.99999907
p_ni:  9.3e-7
Score:  0.638
Data Source:  BioPlex,STRINGDB
AAK1
Tchem
Family:  Kinase
Novelty:  0.02438961
p_int:  0.999995587
p_ni:  0.000004412
p_wrong:  1e-9
Score:  0.88
Data Source:  BioPlex,STRINGDB
EPDR1
Tbio
Novelty:  0.03597825
p_int:  0.99998977
p_ni:  0.00001023
p_wrong:  1e-9
Data Source:  BioPlex
RALBP1
Tbio
Novelty:  0.01525176
p_int:  0.999927725
p_ni:  0.000072275
Score:  0.534
Data Source:  BioPlex,STRINGDB
EPS15L1
Tbio
Novelty:  0.06929299
p_int:  0.999905807
p_ni:  0.000094193
Score:  0.795
Data Source:  BioPlex,STRINGDB
CLIP1
Tbio
Novelty:  0.00399891
p_int:  0.999735778
p_ni:  0.000264208
p_wrong:  1.5e-8
Score:  0.214
Data Source:  BioPlex,STRINGDB
NECAP2
Tdark
Novelty:  0.4141034
p_int:  0.999534879
p_ni:  0.00046512
p_wrong:  1e-9
Score:  0.81
Data Source:  BioPlex,STRINGDB
AP2A2
Tbio
Novelty:  0.08851191
p_int:  0.999451716
p_ni:  0.000548284
Score:  0.778
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
4
5
7
98.4
mean corpuscular volume
2
4
4
98.1
reticulocyte measurement
3
4
6
97.8
mean platelet volume
3
3
4
96.4
mean reticulocyte volume
1
3
3
93.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
7
98.4
mean corpuscular volume
4
98.1
reticulocyte measurement
6
97.8
mean platelet volume
4
96.4
mean reticulocyte volume
3
93.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RUN domain containing 3A
VGNC:51730
739215
Macaque
RUN domain containing 3A
711855
Mouse
MGI:1858752
51799
Rat
RGD:735057
303569
Dog
RUN domain containing 3A
VGNC:45807
480502
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RUN domain containing 3A
Macaque
RUN domain containing 3A
Mouse
Rat
Dog
RUN domain containing 3A
Publication Statistics
PubMed Score 3.86
PubMed score by year
PubTator Score 3.83
PubTator score by year
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Related Publications
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PMID
Year
Title