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Tbio
RUFY4
RUN and FYVE domain-containing protein 4

Protein Summary
Description
Positively regulates macroautophagy in primary dendritic cells. Increases autophagic flux, probably by stimulating both autophagosome formation and facilitating tethering with lysosomes. Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through its FYVE-type zinc finger.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344321
  • ENSP00000345900
  • ENSG00000188282
  • ENST00000457754
  • ENSP00000410091

Symbol
  • ZFYVE31
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.74
cellular component
0.64
tissue
0.56
transcription factor binding site profile
0.52
cell line
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.14   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 54   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.14   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (24)
TRAPPC9
Tbio
Novelty:  0.02703008
p_int:  0.98286684
p_ni:  0.01713316
Score:  0.531
Data Source:  BioPlex,STRINGDB
RUFY2
Tbio
Novelty:  0.50188929
Score:  0.761
Data Source:  STRINGDB
ZNF142
Tdark
Family:  TF
Novelty:  0.46019293
Score:  0.732
Data Source:  STRINGDB
CDK5R2
Tbio
Family:  Enzyme
Novelty:  0.16247335
Score:  0.723
Data Source:  STRINGDB
UAP1L1
Tdark
Family:  Enzyme
Novelty:  0.36065169
Score:  0.678
Data Source:  STRINGDB
STK36
Tbio
Family:  Kinase
Novelty:  0.0963277
Score:  0.663
Data Source:  STRINGDB
TMBIM1
Tbio
Novelty:  0.09770423
Score:  0.625
Data Source:  STRINGDB
TTLL7
Tbio
Family:  Enzyme
Novelty:  0.14162171
Score:  0.557
Data Source:  STRINGDB
RAB33A
Tbio
Family:  Enzyme
Novelty:  0.11617001
Score:  0.539
Data Source:  STRINGDB
AMPD3
Tchem
Family:  Enzyme
Novelty:  0.01230806
Score:  0.501
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
4
7
98.1
lymphocyte percentage of leukocytes
2
4
6
97
leukocyte count
2
3
5
95.7
myeloid white cell count
3
3
4
95.7
neutrophil percentage of leukocytes
2
3
5
95.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
7
98.1
lymphocyte percentage of leukocytes
6
97
leukocyte count
5
95.7
myeloid white cell count
4
95.7
neutrophil percentage of leukocytes
5
95.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:3588214
435626
Rat
RGD:1560678
301510
Dog
RUN and FYVE domain containing 4
488520
Horse
RUN and FYVE domain containing 4 [Source:HGNC Symbol;Acc:HGNC:24804]
Cow
RUN and FYVE domain containing 4
VGNC:34216
523588
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
RUN and FYVE domain containing 4
Horse
RUN and FYVE domain containing 4 [Source:HGNC Symbol;Acc:HGNC:24804]
Cow
RUN and FYVE domain containing 4
Publication Statistics
PubMed Score 2.14
PubMed score by year
PubTator Score 0.50
PubTator score by year
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Related Publications
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PMID
Year
Title