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Tbio
RUFY3
Protein RUFY3

Protein Summary
Description
Plays a role in the generation of neuronal polarity formation and axon growth (By similarity). Implicated in the formation of a single axon by developing neurons (By similarity). May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes (By similarity). Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery (PubMed:25766321). Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones (By similarity). Promotes gastric cancer cell migration and invasion in a PAK1-dependent manner (PubMed:25766321). This gene encodes a RPIP8, UNC-14, and NESCA domain-containing protein that is required for maintenance of neuronal polarity. In addition, it has been implicated in mediation of gastric cancer cell migration and invasion via interaction with P21-activated kinase-1, which promotes its expression. The encoded protein localizes to F-actin-enriched invadop ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000226328
  • ENSP00000226328
  • ENSG00000018189
  • ENST00000381006
  • ENSP00000370394
  • ENST00000417478
  • ENSP00000399771
  • ENST00000502653
  • ENSP00000425400

Symbol
  • KIAA0871
  • RIPX
  • SINGAR1
  • ZFYVE30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
disease perturbation
0.87
microRNA
0.78
tissue
0.65
virus perturbation
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (32)
RUFY1
Tbio
Novelty:  0.16796947
p_int:  0.999923129
p_ni:  0.000076871
Score:  0.522
Data Source:  BioPlex,STRINGDB
DCAF15
Tdark
Novelty:  0.13476661
p_int:  0.999678435
p_ni:  0.000321565
Score:  0.228
Data Source:  BioPlex,STRINGDB
RUFY2
Tbio
Novelty:  0.50188929
p_int:  0.983485448
p_ni:  0.016514552
Score:  0.693
Data Source:  BioPlex,STRINGDB
TRMT9B
Tbio
Family:  Enzyme
Novelty:  0.26285485
p_int:  0.97424214
p_ni:  0.02575786
Score:  0.53
Data Source:  BioPlex,STRINGDB
DHX33
Tbio
Family:  Enzyme
Novelty:  0.07473852
p_int:  0.960618201
p_ni:  0.039381799
Data Source:  BioPlex
GLT1D1
Tdark
Family:  Enzyme
Novelty:  0.33685691
p_int:  0.927620204
p_ni:  0.072379796
Score:  0.325
Data Source:  BioPlex,STRINGDB
PRUNE1
Tchem
Novelty:  0.02136836
p_int:  0.91426834
p_ni:  0.08573166
Data Source:  BioPlex
ADAMTS12
Tbio
Family:  Enzyme
Novelty:  0.03184816
p_int:  0.879645309
p_ni:  0.120354691
Score:  0.187
Data Source:  BioPlex,STRINGDB
CHIA
Tchem
Family:  Enzyme
Novelty:  0.00181726
p_int:  0.838710134
p_ni:  0.161289866
p_wrong:  1e-9
Score:  0.151
Data Source:  BioPlex,STRINGDB
GANAB
Tchem
Family:  Enzyme
Novelty:  0.01211958
p_int:  0.824991941
p_ni:  0.175008059
Score:  0.19
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
HGNC
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Drugs used in diabetes use measurement
2
2
2
49.1
type 2 diabetes mellitus
2
2
1
1.1
46
red blood cell distribution width
1
1
1
35.6
body fat percentage
1
1
1
33.4
serum metabolite measurement
1
1
1
9.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Drugs used in diabetes use measurement
2
49.1
type 2 diabetes mellitus
1
1.1
46
red blood cell distribution width
1
35.6
body fat percentage
1
33.4
serum metabolite measurement
1
9.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RUN and FYVE domain containing 3
VGNC:12969
461275
Macaque
RUN and FYVE domain containing 3
706417
Mouse
MGI:106484
52822
Rat
RGD:1565242
360921
Dog
RUN and FYVE domain containing 3
VGNC:45805
475168
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RUN and FYVE domain containing 3
Macaque
RUN and FYVE domain containing 3
Mouse
Rat
Dog
RUN and FYVE domain containing 3
Publication Statistics
PubMed Score 15.00
PubMed score by year
PubTator Score 4.01
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title