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Tbio
RUFY1
RUN and FYVE domain-containing protein 1

Protein Summary
Description
Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking. This gene encodes a protein that contains a RUN domain and a FYVE-type zinc finger domain. The encoded protein binds to phosphatidylinositol-3-phosphate (PI3P) and plays a role in early endosomal trafficking, tethering and fusion through interactions with small GTPases including Rab4, Rab5 and Rab14. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319449
  • ENSP00000325594
  • ENSG00000176783
  • ENST00000393438
  • ENSP00000377087
  • ENST00000437570
  • ENSP00000390025
  • ENST00000639102
  • ENSP00000491803
  • ENSG00000284260
  • ENST00000639436
  • ENSP00000491925
  • ENST00000639909
  • ENSP00000492748

Symbol
  • RABIP4
  • ZFYVE12
  • RABIP4
  • ZFYVE12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
protein domain
0.85
tissue sample
0.75
interacting protein
0.72
transcription factor binding site profile
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.01   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 194   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.01   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0