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Tbio
RUFY1
RUN and FYVE domain-containing protein 1

Protein Summary
Description
Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking. This gene encodes a protein that contains a RUN domain and a FYVE-type zinc finger domain. The encoded protein binds to phosphatidylinositol-3-phosphate (PI3P) and plays a role in early endosomal trafficking, tethering and fusion through interactions with small GTPases including Rab4, Rab5 and Rab14. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319449
  • ENSP00000325594
  • ENSG00000176783
  • ENST00000393438
  • ENSP00000377087
  • ENST00000437570
  • ENSP00000390025
  • ENST00000639102
  • ENSP00000491803
  • ENSG00000284260
  • ENST00000639436
  • ENSP00000491925
  • ENST00000639909
  • ENSP00000492748

Symbol
  • RABIP4
  • ZFYVE12
  • RABIP4
  • ZFYVE12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
protein domain
0.85
tissue sample
0.75
interacting protein
0.72
transcription factor binding site profile
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.12   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 194   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.12   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
RUFY2
Tbio
Novelty:  0.50188929
p_int:  1
Score:  0.815
Data Source:  BioPlex,STRINGDB
PMF1
Tbio
Novelty:  0.05319446
p_int:  0.999924598
p_ni:  0.000075402
Data Source:  BioPlex
RUFY3
Tbio
Novelty:  0.1517817
p_int:  0.999923129
p_ni:  0.000076871
Score:  0.522
Data Source:  BioPlex,STRINGDB
SYNC
Tbio
Novelty:  0.04605223
p_int:  0.999668536
p_ni:  0.000331275
p_wrong:  1.89e-7
Data Source:  BioPlex
WDFY2
Tbio
Novelty:  0.01835759
p_int:  0.999263933
p_ni:  0.000736067
Score:  0.189
Data Source:  BioPlex,STRINGDB
SNX8
Tbio
Novelty:  0.02652492
p_int:  0.997741223
p_ni:  0.002258774
p_wrong:  2e-9
Score:  0.233
Data Source:  BioPlex,STRINGDB
RUBCNL
Tbio
Novelty:  0.20019585
p_int:  0.996859829
p_ni:  0.003140171
Score:  0.517
Data Source:  BioPlex,STRINGDB
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.994615778
p_ni:  0.005357358
p_wrong:  0.000026864
Data Source:  BioPlex
CD79B
Tclin
Novelty:  0.00227414
p_int:  0.993352407
p_ni:  0.006647593
Data Source:  BioPlex
FAM9C
Tdark
Novelty:  0.86727989
p_int:  0.99035804
p_ni:  0.009637186
p_wrong:  0.000004773
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Reactome
Synthesis of PIPs at the plasma membrane
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Synthesis of PIPs at the plasma membrane
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
2
2
2
81.8
myeloid white cell count
2
2
2
81.8
leukocyte count
2
2
2
74
leukocyte count
2
2
2
74
neutrophil count
1
1
1
69.8
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
2
81.8
myeloid white cell count
2
81.8
leukocyte count
2
74
leukocyte count
2
74
neutrophil count
1
69.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RUN and FYVE domain containing 1
VGNC:53271
462328
Mouse
MGI:2429762
216724
Rat
RGD:1305099
360521
Dog
RUN and FYVE domain containing 1
VGNC:45803
481454
Horse
RUN and FYVE domain containing 1
VGNC:22624
100067514
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RUN and FYVE domain containing 1
Mouse
Rat
Dog
RUN and FYVE domain containing 1
Horse
RUN and FYVE domain containing 1
Publication Statistics
PubMed Score 7.12
PubMed score by year
PubTator Score 5.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title