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Tbio
RUBCNL
Protein RUBCNL-like

Protein Summary
Description
May act as a tumor suppressor. This gene encodes a cysteine-rich protein that contains a putative zinc-RING and/or ribbon domain. The encoded protein is related to Run domain Beclin-1-interacting and cysteine-rich domain-containing protein, which plays a role in endocytic trafficking and autophagy. In cervical cancer cell lines, this gene is expressed at low levels and may function as a tumor suppressor. Promoter hypermethylation of this gene is observed in cervical cancer cell lines and tissue derived from human patients. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378784
  • ENSP00000368061
  • ENSG00000102445
  • ENST00000378787
  • ENSP00000368064
  • ENST00000389908
  • ENSP00000374558
  • ENST00000429979
  • ENSP00000396935
  • ENST00000631139
  • ENSP00000485932

Symbol
  • C13orf18
  • KIAA0226L
  • PACER
  • C13orf18
  • KIAA0226L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.84   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.84   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
UVRAG
Tbio
Novelty:  0.01081083
p_int:  1
Score:  0.635
Data Source:  BioPlex,STRINGDB
PIK3C3
Tchem
Family:  Kinase
Novelty:  0.00269825
p_int:  0.999999984
p_ni:  1.6e-8
Score:  0.396
Data Source:  BioPlex,STRINGDB
BECN1
Tbio
Novelty:  0.0003792
p_int:  0.999999975
p_ni:  1.6e-8
p_wrong:  9e-9
Score:  0.521
Data Source:  BioPlex,STRINGDB
GRK6
Tchem
Family:  Kinase
Novelty:  0.02740874
p_int:  0.999051641
p_ni:  0.000939456
p_wrong:  0.000008903
Data Source:  BioPlex
PIK3R4
Tbio
Family:  Kinase
Novelty:  0.01412698
p_int:  0.998789947
p_ni:  0.001210053
Score:  0.327
Data Source:  BioPlex,STRINGDB
RUFY1
Tbio
Novelty:  0.16796947
p_int:  0.996859829
p_ni:  0.003140171
Score:  0.517
Data Source:  BioPlex,STRINGDB
SEC24A
Tbio
Novelty:  0.07724534
p_int:  0.824474999
p_ni:  0.175525001
Score:  0.54
Data Source:  BioPlex,STRINGDB
SEC23B
Tbio
Novelty:  0.02307622
p_int:  0.824032651
p_ni:  0.175967349
Score:  0.544
Data Source:  BioPlex,STRINGDB
CWC25
Tdark
Novelty:  0.13727856
Score:  0.841
Data Source:  STRINGDB
LIX1
Tbio
Novelty:  0.03028158
Score:  0.841
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RUN and cysteine rich domain containing beclin 1 interacting protein like
VGNC:51888
452587
Horse
RUN and cysteine rich domain containing beclin 1 interacting protein like
VGNC:22623
100058229
Cow
RUN and cysteine rich domain containing beclin 1 interacting protein like
VGNC:34213
517231
Opossum
RUN and cysteine rich domain containing beclin 1 interacting protein like
100029236
Platypus
RUN and cysteine rich domain containing beclin 1 interacting protein like [Source:HGNC Symbol;Acc:HGNC:20420]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RUN and cysteine rich domain containing beclin 1 interacting protein like
Horse
RUN and cysteine rich domain containing beclin 1 interacting protein like
Cow
RUN and cysteine rich domain containing beclin 1 interacting protein like
Opossum
RUN and cysteine rich domain containing beclin 1 interacting protein like
Platypus
RUN and cysteine rich domain containing beclin 1 interacting protein like [Source:HGNC Symbol;Acc:HGNC:20420]
Publication Statistics
PubMed Score 5.84
PubMed score by year
PubTator Score 6.42
PubTator score by year
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Related Publications
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PMID
Year
Title