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Tbio
RUBCNL
Protein RUBCNL-like

Protein Summary
Description
May act as a tumor suppressor. This gene encodes a cysteine-rich protein that contains a putative zinc-RING and/or ribbon domain. The encoded protein is related to Run domain Beclin-1-interacting and cysteine-rich domain-containing protein, which plays a role in endocytic trafficking and autophagy. In cervical cancer cell lines, this gene is expressed at low levels and may function as a tumor suppressor. Promoter hypermethylation of this gene is observed in cervical cancer cell lines and tissue derived from human patients. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378784
  • ENSP00000368061
  • ENSG00000102445
  • ENST00000378787
  • ENSP00000368064
  • ENST00000389908
  • ENSP00000374558
  • ENST00000429979
  • ENSP00000396935
  • ENST00000631139
  • ENSP00000485932

Symbol
  • C13orf18
  • KIAA0226L
  • PACER
  • C13orf18
  • KIAA0226L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.24   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.24   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0