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Tbio
RUBCN
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein

Protein Summary
Description
Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (PubMed:20974968, PubMed:21062745). Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines (PubMed:22423966). Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or DDX58/RIG-I-dependent sensin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273582
  • ENSP00000273582
  • ENSG00000145016
  • ENST00000296343
  • ENSP00000296343

Symbol
  • KIAA0226
  • SCAR15
  • RUBICON
  • KIAA0226
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.73   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.73   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
UVRAG
Tbio
Novelty:  0.01081083
Score:  0.987
Data Source:  STRINGDB
BECN1
Tbio
Novelty:  0.0003792
Score:  0.95
Data Source:  STRINGDB
PIK3C3
Tchem
Family:  Kinase
Novelty:  0.00269825
Score:  0.945
Data Source:  STRINGDB
PIK3R4
Tbio
Family:  Kinase
Novelty:  0.01412698
Score:  0.867
Data Source:  STRINGDB
ATG14
Tbio
Novelty:  0.00914791
Score:  0.828
Data Source:  STRINGDB
AMBRA1
Tbio
Novelty:  0.01626687
Score:  0.789
Data Source:  STRINGDB
RAB7B
Tbio
Family:  Enzyme
Novelty:  0.00207354
Score:  0.749
Data Source:  STRINGDB
RAB7A
Tchem
Family:  Enzyme
Novelty:  0.00192702
Score:  0.743
Data Source:  STRINGDB
EGFR
Tclin
Family:  Kinase
Novelty:  0.00007274
Score:  0.723
Data Source:  STRINGDB
ATG5
Tbio
Novelty:  0.00081472
Score:  0.675
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
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1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RUN and cysteine rich domain containing beclin 1 interacting protein
VGNC:14235
Mouse
MGI:1915160
100502698
Dog
RUN and cysteine rich domain containing beclin 1 interacting protein
VGNC:45801
100856511
Horse
RUN and cysteine rich domain containing beclin 1 interacting protein
VGNC:22622
100070138
Cow
RUN and cysteine rich domain containing beclin 1 interacting protein
VGNC:34212
508354
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RUN and cysteine rich domain containing beclin 1 interacting protein
Mouse
Dog
RUN and cysteine rich domain containing beclin 1 interacting protein
Horse
RUN and cysteine rich domain containing beclin 1 interacting protein
Cow
RUN and cysteine rich domain containing beclin 1 interacting protein
Publication Statistics
PubMed Score 38.73
PubMed score by year
PubTator Score 82.76
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title