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Tbio
RTP4
Receptor-transporting protein 4

Protein Summary
Description
Probable chaperone protein which facilitates trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs). Promotes functional expression of the bitter taste receptor TAS2R16 (PubMed:16720576). Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259030
  • ENSP00000259030
  • ENSG00000136514

Symbol
  • IFRG28
  • Z3CXXC4
  • IFRG28
  • Z3CXXC4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
gene perturbation
0.98
transcription factor perturbation
0.84
PubMedID
0.73
tissue sample
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.36   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.36   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (448)
OR4C15
Tdark
Family:  oGPCR
Novelty:  12.71580262
Score:  0.928
Data Source:  STRINGDB
OR8B3
Tdark
Family:  oGPCR
Novelty:  0.75670011
Score:  0.913
Data Source:  STRINGDB
OR10D3
Tdark
Family:  oGPCR
Novelty:  10
Score:  0.913
Data Source:  STRINGDB
OR8B2
Tdark
Family:  oGPCR
Score:  0.913
Data Source:  STRINGDB
OR6T1
Tdark
Family:  oGPCR
Novelty:  35
Score:  0.909
Data Source:  STRINGDB
GNAL
Tbio
Novelty:  0.01757098
Score:  0.907
Data Source:  STRINGDB
OR51H1
Tdark
Family:  oGPCR
Novelty:  17
Score:  0.906
Data Source:  STRINGDB
OR51F2
Tdark
Family:  oGPCR
Novelty:  1.99313574
Score:  0.906
Data Source:  STRINGDB
OR51A7
Tdark
Family:  oGPCR
Novelty:  4.11736092
Score:  0.906
Data Source:  STRINGDB
OR51S1
Tdark
Family:  oGPCR
Novelty:  0.87804878
Score:  0.906
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
G alpha (s) signalling events (R-HSA-418555)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
Olfactory Signaling Pathway
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (s) signalling events
GPCR downstream signalling
Olfactory Signaling Pathway
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
1
1
0
1.6
8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
0
1.6
8
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
receptor transporter protein 4
708404
Mouse
MGI:1915025
67775
Rat
RGD:1306974
360733
Dog
receptor transporter protein 4
VGNC:53463
488122
Anole lizard
receptor-transporting protein 2-like
103281311
Species
Name
OMA
EggNOG
Inparanoid
Macaque
receptor transporter protein 4
Mouse
Rat
Dog
receptor transporter protein 4
Anole lizard
receptor-transporting protein 2-like
Publication Statistics
PubMed Score 18.36
PubMed score by year
PubTator Score 3.14
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title