Tbio RTP4 Receptor-transporting protein 4

Protein Summary

Description

Probable chaperone protein which facilitates trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs). Promotes functional expression of the bitter taste receptor TAS2R16 (PubMed:16720576). Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (By similarity).

Uniprot Accession IDs

• Q96DX8
• Q9H4F3

Gene Name

• RTP4

Ensembl ID

• ENST00000259030
• ENSP00000259030
• ENSG00000136514

Symbol

• IFRG28
• Z3CXXC4
• IFRG28
• Z3CXXC4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
gene perturbation	0.98
transcription factor perturbation	0.84
PubMedID	0.73
tissue sample	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.36   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 103   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.36   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (448)

Explore Interacting Targets

1 – 10 of 448

• See Interactions on String-DB

OR4C15

Tdark

Family:  oGPCR

Novelty:  12.71580262

Score:  0.928

Data Source:  STRINGDB

OR8B3

Tdark

Family:  oGPCR

Novelty:  0.75670011

Score:  0.913

Data Source:  STRINGDB

OR10D3

Tdark

Family:  oGPCR

Novelty:  10

Score:  0.913

Data Source:  STRINGDB

OR8B2

Tdark

Family:  oGPCR

Score:  0.913

Data Source:  STRINGDB

OR6T1

Tdark

Family:  oGPCR

Novelty:  35

Score:  0.909

Data Source:  STRINGDB

GNAL

Tbio

Novelty:  0.01757098

Score:  0.907

Data Source:  STRINGDB

OR51H1

Tdark

Family:  oGPCR

Novelty:  17

Score:  0.906

Data Source:  STRINGDB

OR51F2

Tdark

Family:  oGPCR

Novelty:  1.99313574

Score:  0.906

Data Source:  STRINGDB

OR51A7

Tdark

Family:  oGPCR

Novelty:  4.11736092

Score:  0.906

Data Source:  STRINGDB

OR51S1

Tdark

Family:  oGPCR

Novelty:  0.87804878

Score:  0.906

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (5)

Reactome (5)

G alpha (s) signalling events (R-HSA-418555)

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5

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	G alpha (s) signalling events	577 targets	R-HSA-418555
Reactome	GPCR downstream signalling	1152 targets	R-HSA-388396
Reactome	Olfactory Signaling Pathway	431 targets	R-HSA-381753
Reactome	Signal Transduction	2704 targets	R-HSA-162582
Reactome	Signaling by GPCR	1212 targets	R-HSA-372790

Name	Explore in Pharos	Explore in Source
G alpha (s) signalling events	577 targets	R-HSA-418555
GPCR downstream signalling	1152 targets	R-HSA-388396
Olfactory Signaling Pathway	431 targets	R-HSA-381753
Signal Transduction	2704 targets	R-HSA-162582
Signaling by GPCR	1212 targets	R-HSA-372790

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (8)

Functions (1)

Components (3)

Processes (4)

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10

1 – 1 of 1

GO Term	Evidence	Assigned by
olfactory receptor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (1)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
central corneal thickness	EFO_0005213	1	1	0	1.6	8

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
central corneal thickness	EFO_0005213	0	1.6	8

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UniProt Keyword Find Similar Targets

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Complete proteome
Membrane
Polymorphism
Reference proteome
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Transmembrane helix

GWAS Trait Find Similar Targets

No Header	No Header
central corneal thickness

IDG Resources

No IDG generated resources found

Orthologs (5)

1 – 5 of 5

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	receptor transporter protein 4		708404
Mouse	receptor transporter protein 4	MGI:1915025	67775
Rat	receptor (chemosensory) transporter protein 4	RGD:1306974	360733
Dog	receptor transporter protein 4	VGNC:53463	488122
Anole lizard	receptor-transporting protein 2-like		103281311

Species	Name	OMA	EggNOG	Inparanoid
Macaque	receptor transporter protein 4
Mouse	receptor transporter protein 4
Rat	receptor (chemosensory) transporter protein 4
Dog	receptor transporter protein 4
Anole lizard	receptor-transporting protein 2-like

Publication Statistics

PubMed Score 18.36

PubMed score by year

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PubTator Score 3.14

PubTator score by year

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Related Publications

Text Mined References (7)

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10

0 of 0

PMID	Year	Title