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Tbio
RTN4RL2
Reticulon-4 receptor-like 2

Protein Summary
Description
Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335099
  • ENSP00000335397
  • ENSG00000186907
  • ENST00000395120
  • ENSP00000378552

Symbol
  • NGRH1
  • NGRL3
  • NgR2
  • NGRH1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.7
histone modification site profile
0.65
transcription factor binding site profile
0.62
tissue sample
0.61
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.25   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.25   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (93)
LCN6
Tbio
Novelty:  0.11406686
p_int:  0.999687921
p_ni:  0.000203472
p_wrong:  0.000108608
Data Source:  BioPlex
NRROS
Tbio
Novelty:  0.08976002
p_int:  0.994532172
p_ni:  0.000722031
p_wrong:  0.004745797
Score:  0.195
Data Source:  BioPlex,STRINGDB
LGALS3
Tchem
Novelty:  0.00032754
p_int:  0.993900261
p_ni:  0.000831052
p_wrong:  0.005268687
Score:  0.22
Data Source:  BioPlex,STRINGDB
IL20
Tbio
Novelty:  0.78184288
p_int:  0.881585663
p_ni:  0.002716177
p_wrong:  0.11569816
Data Source:  BioPlex
NTNG1
Tbio
Novelty:  0.04742965
Score:  0.914
Data Source:  STRINGDB
CNTN5
Tbio
Novelty:  0.00601105
Score:  0.911
Data Source:  STRINGDB
CNTN3
Tbio
Novelty:  0.0055725
Score:  0.91
Data Source:  STRINGDB
RTN4RL1
Tbio
Novelty:  0.07113722
Score:  0.91
Data Source:  STRINGDB
CNTN4
Tbio
Novelty:  0.02483465
Score:  0.91
Data Source:  STRINGDB
NTNG2
Tbio
Novelty:  0.02827688
Score:  0.907
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
4
4
91.9
pappalysin‐1 measurement
1
2
2
89.6
eosinophil percentage of leukocytes
2
3
3
80.7
1
1
1
51.7
mathematical ability
2
1
2
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
4
91.9
pappalysin‐1 measurement
2
89.6
eosinophil percentage of leukocytes
3
80.7
1
51.7
mathematical ability
2
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
reticulon 4 receptor like 2 [Source:HGNC Symbol;Acc:HGNC:23053]
Mouse
MGI:2669796
269295
Rat
RGD:727797
311169
Dog
reticulon 4 receptor like 2
VGNC:52041
610197
Cow
reticulon 4 receptor like 2
VGNC:34208
529030
Species
Name
OMA
EggNOG
Inparanoid
Macaque
reticulon 4 receptor like 2 [Source:HGNC Symbol;Acc:HGNC:23053]
Mouse
Rat
Dog
reticulon 4 receptor like 2
Cow
reticulon 4 receptor like 2
Publication Statistics
PubMed Score 19.25
PubMed score by year
PubTator Score 9.74
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title