RTN4RL2
Reticulon-4 receptor-like 2
Protein Summary
Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200).
- ENST00000335099
- ENSP00000335397
- ENSG00000186907
- ENST00000395120
- ENSP00000378552
- NGRH1
- NGRL3
- NgR2
- NGRH1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cellular component | 0.7 | ||
histone modification site profile | 0.65 | ||
transcription factor binding site profile | 0.62 | ||
tissue sample | 0.61 | ||
protein domain | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19.25 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 130 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19.25 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 130 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (93)
LCN6
Novelty: 0.11406686
p_int: 0.999687921
p_ni: 0.000203472
p_wrong: 0.000108608
Data Source: BioPlex
NRROS
Novelty: 0.08976002
p_int: 0.994532172
p_ni: 0.000722031
p_wrong: 0.004745797
Score: 0.195
Data Source: BioPlex,STRINGDB
LGALS3
Novelty: 0.00032754
p_int: 0.993900261
p_ni: 0.000831052
p_wrong: 0.005268687
Score: 0.22
Data Source: BioPlex,STRINGDB
IL20
Novelty: 0.78184288
p_int: 0.881585663
p_ni: 0.002716177
p_wrong: 0.11569816
Data Source: BioPlex
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism of proteins | ||||
Reactome | Post-translational modification: synthesis of GPI-anchored proteins | ||||
Reactome | Post-translational protein modification | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism of proteins | ||||
Post-translational modification: synthesis of GPI-anchored proteins | ||||
Post-translational protein modification | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (1)
Components (13)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
eosinophil count | 3 | 4 | 4 | 91.9 | |||||
pappalysinâ1 measurement | 1 | 2 | 2 | 89.6 | |||||
eosinophil percentage of leukocytes | 2 | 3 | 3 | 80.7 | |||||
1 | 1 | 1 | 51.7 | ||||||
mathematical ability | 2 | 1 | 2 | 49.5 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
eosinophil count | 4 | 91.9 | |||||
pappalysinâ1 measurement | 2 | 89.6 | |||||
eosinophil percentage of leukocytes | 3 | 80.7 | |||||
1 | 51.7 | ||||||
mathematical ability | 2 | 49.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | reticulon 4 receptor like 2 [Source:HGNC Symbol;Acc:HGNC:23053] | |||||||
Mouse | MGI:2669796 | 269295 | ||||||
Rat | RGD:727797 | 311169 | ||||||
Dog | reticulon 4 receptor like 2 | VGNC:52041 | 610197 | |||||
Cow | reticulon 4 receptor like 2 | VGNC:34208 | 529030 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | reticulon 4 receptor like 2 [Source:HGNC Symbol;Acc:HGNC:23053] | |||||
Mouse | ||||||
Rat | ||||||
Dog | reticulon 4 receptor like 2 | |||||
Cow | reticulon 4 receptor like 2 | |||||
Publication Statistics
PubMed Score 19.25
PubMed score by year
PubTator Score 9.74
PubTator score by year
Related Publications
Text Mined References (14)
GeneRif Annotations (5)
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PMID | Year | Title |
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