Tbio RTN4 Reticulon-4

Protein Summary

Description

Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing. Induces the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:25612671, PubMed:24262037, PubMed:27619977). Regulates membrane morphogenesis in the ER by promoting tubular ER production (PubMed:27619977). Influences NE expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NQC3
• O94962
• Q7L7Q5
• Q7L7Q6
• Q7L7Q8
• Q8IUA4
• Q96B16
• Q9BXG5
• Q9H212
• Q9H3I3
• Q9UQ42
• Q9Y293
• Q9Y2Y7
• Q9Y5U6

Gene Name

• RTN4

Ensembl ID

• ENST00000317610
• ENSP00000322147
• ENSG00000115310
• ENST00000337526
• ENSP00000337838
• ENST00000357376
• ENSP00000349944
• ENST00000357732
• ENSP00000350365
• ENST00000394609
• ENSP00000378107
• ENST00000394611
• ENSP00000378109
• ENST00000404909
• ENSP00000385650
• ENST00000405240
• ENSP00000384471

Symbol

• KIAA0886
• NOGO
• ASY
• NSP
• NOGO
• RTN-X
• NSP-CL
• RTN4-A
• RTN4-C
• RTN4-B1
• RTN4-B2
• NI220/250
• Nbla00271
• Nbla10545

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
disease perturbation	0.99
kinase perturbation	0.99
transcription factor binding site profile	0.99
co-expressed gene	0.97

Protein Classes

DTO Classes

Reticulon-4 Receptor-like 2 / Reticulon-4 Receptor-like 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1433.89   (req: < 5)

Gene RIFs: 121   (req: <= 3)

Antibodies: 481   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1433.89   (req: >= 5)

Gene RIFs: 121   (req: > 3)

Antibodies: 481   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0