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Tbio
RTN4
Reticulon-4

Protein Summary
Description
Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing. Induces the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:25612671, PubMed:24262037, PubMed:27619977). Regulates membrane morphogenesis in the ER by promoting tubular ER production (Pub ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317610
  • ENSP00000322147
  • ENSG00000115310
  • ENST00000337526
  • ENSP00000337838
  • ENST00000357376
  • ENSP00000349944
  • ENST00000357732
  • ENSP00000350365
  • ENST00000394609
  • ENSP00000378107
  • ENST00000394611
  • ENSP00000378109
  • ENST00000404909
  • ENSP00000385650
  • ENST00000405240
  • ENSP00000384471

Symbol
  • KIAA0886
  • NOGO
  • ASY
  • NSP
  • NOGO
  • RTN-X
  • NSP-CL
  • RTN4-A
  • RTN4-C
  • RTN4-B1
  • RTN4-B2
  • NI220/250
  • Nbla00271
  • Nbla10545
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
disease perturbation
0.99
kinase perturbation
0.99
transcription factor binding site profile
0.99
co-expressed gene
0.97


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1433.89   (req: < 5)
Gene RIFs: 95   (req: <= 3)
Antibodies: 481   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1433.89   (req: >= 5)
Gene RIFs: 95   (req: > 3)
Antibodies: 481   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0