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Tbio
RTN3
Reticulon-3

Protein Summary
Description
May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671). This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339997
  • ENSP00000344106
  • ENSG00000133318
  • ENST00000341307
  • ENSP00000340903
  • ENST00000354497
  • ENSP00000346492
  • ENST00000356000
  • ENSP00000348279
  • ENST00000377819
  • ENSP00000367050
  • ENST00000537981
  • ENSP00000440874
  • ENST00000540798
  • ENSP00000442733

Symbol
  • ASYIP
  • NSPL2
  • HAP
  • ASYIP
  • NSPL2
  • NSPLII
  • RTN3-A1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
virus perturbation
0.98
ligand (protein) perturbation
0.96
transcription factor binding site profile
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.85   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.85   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
FAM241A
Tdark
Novelty:  1.04041354
p_int:  0.95844006
p_ni:  0.04155994
Data Source:  BioPlex
RTN4
Tbio
Novelty:  0.00080371
p_int:  0.787187221
p_ni:  0.212812779
Score:  0.905
Data Source:  BioPlex,STRINGDB
LRFN2
Tbio
Novelty:  0.07450569
Score:  0.919
Data Source:  Reactome,STRINGDB
LRFN1
Tdark
Novelty:  0.21439206
Score:  0.908
Data Source:  STRINGDB
LRFN3
Tdark
Novelty:  0.30018245
Score:  0.906
Data Source:  Reactome,STRINGDB
LRFN4
Tbio
Novelty:  0.12511571
Score:  0.906
Data Source:  STRINGDB
BACE1
Tchem
Family:  Enzyme
Novelty:  0.00042175
Score:  0.8
Data Source:  STRINGDB
REEP5
Tbio
Novelty:  0.00160455
Score:  0.766
Data Source:  STRINGDB
SLC30A3
Tbio
Family:  Transporter
Novelty:  0.00683607
Score:  0.732
Data Source:  STRINGDB
VTA1
Tbio
Novelty:  0.01697854
Score:  0.731
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Reactome
Synaptic adhesion-like molecules
Name
Explore in Pharos
Explore in Source
Neuronal System
Protein-protein interactions at synapses
Synaptic adhesion-like molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
1
1
5.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
5.9
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
reticulon 3
VGNC:11663
451281
Macaque
reticulon 3
718173
Mouse
MGI:1339970
20168
Rat
RGD:620988
140945
Pig
reticulon 3
100512087
Species
Name
OMA
EggNOG
Inparanoid
Chimp
reticulon 3
Macaque
reticulon 3
Mouse
Rat
Pig
reticulon 3
Publication Statistics
PubMed Score 53.85
PubMed score by year
PubTator Score 115.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title