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Tbio
RTN2
Reticulon-2

Protein Summary
Description
This gene belongs to the family of reticulon encoding genes. Reticulons are necessary for proper generation of tubular endoplasmic reticulum and likely play a role in intracellular vesicular transport. Alternatively spliced transcript variants encoding different isoforms have been identified. Mutations at this locus have been associated with autosomal dominant spastic paraplegia-12. [provided by RefSeq, Apr 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245923
  • ENSP00000245923
  • ENSG00000125744
  • ENST00000344680
  • ENSP00000345127
  • ENST00000430715
  • ENSP00000398178

Symbol
  • NSPL1
  • NSP2
  • NSPL1
  • NSPLI
  • SPG12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.78
tissue sample
0.69
cellular component
0.67
transcription factor binding site profile
0.63
transcription factor
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.42   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 132   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.42   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (106)
RTN1
Tbio
Novelty:  0.01828064
p_int:  0.999954009
p_ni:  0.000045983
p_wrong:  8e-9
Score:  0.648
Data Source:  BioPlex,STRINGDB
RTN4
Tbio
Novelty:  0.00080371
p_int:  0.999906476
p_ni:  0.000093394
p_wrong:  1.3e-7
Score:  0.653
Data Source:  BioPlex,STRINGDB
FAM241A
Tdark
Novelty:  1.04041354
p_int:  0.999860008
p_ni:  0.000139972
p_wrong:  2e-8
Data Source:  BioPlex
TMEM128
Tdark
Novelty:  5.15874803
p_int:  0.9996495
p_ni:  0.000350493
p_wrong:  7e-9
Score:  0.195
Data Source:  BioPlex,STRINGDB
C11orf87
Tdark
Novelty:  1.33249342
p_int:  0.999364709
p_ni:  0.000580998
p_wrong:  0.000054293
Data Source:  BioPlex
FPR2
Tchem
Family:  GPCR
Novelty:  0.00228744
p_int:  0.995884408
p_ni:  0.004115526
p_wrong:  6.6e-8
Data Source:  BioPlex
SVOPL
Tdark
Novelty:  0.46448049
p_int:  0.99326962
p_ni:  0.00670502
p_wrong:  0.00002536
Data Source:  BioPlex
VTN
Tbio
Family:  TF
Novelty:  0.00046861
p_int:  0.99286926
p_ni:  0.005076105
p_wrong:  0.002054635
Data Source:  BioPlex
LPAR1
Tchem
Family:  GPCR
Novelty:  0.00318056
p_int:  0.988957597
p_ni:  0.009879354
p_wrong:  0.001163049
Data Source:  BioPlex
GYPB
Tbio
Novelty:  0.00442195
p_int:  0.988533694
p_ni:  0.00590674
p_wrong:  0.005559567
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
4
6
91.1
apolipoprotein B measurement
1
4
4
87.4
low density lipoprotein cholesterol measurement
1
3
3
76.7
C-reactive protein measurement
2
3
3
71.8
platelet count
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
6
91.1
apolipoprotein B measurement
4
87.4
low density lipoprotein cholesterol measurement
3
76.7
C-reactive protein measurement
3
71.8
platelet count
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
reticulon 2
715941
Mouse
MGI:107612
20167
Rat
RGD:1303245
308410
Dog
reticulon 2
VGNC:53971
484444
Horse
reticulon 2
VGNC:49261
100147095
Species
Name
OMA
EggNOG
Inparanoid
Macaque
reticulon 2
Mouse
Rat
Dog
reticulon 2
Horse
reticulon 2
Publication Statistics
PubMed Score 18.42
PubMed score by year
PubTator Score 271.99
PubTator score by year
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Related Publications
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PMID
Year
Title