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Tbio
RTN1
Reticulon-1

Protein Summary
Description
May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. This gene is considered to be a specific marker for neurological diseases and cancer, and is a potential molecular target for therapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267484
  • ENSP00000267484
  • ENSG00000139970
  • ENST00000342503
  • ENSP00000340716

Symbol
  • NSP
  • NSP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
PubMedID
0.94
kinase perturbation
0.91
hub protein
0.75
transcription factor perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.17   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 455   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.17   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 455   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (141)
DYRK2
Tchem
Family:  Kinase
Novelty:  0.01724243
p_int:  0.999999972
p_ni:  9e-9
p_wrong:  2e-8
Score:  0.31
Data Source:  BioPlex,STRINGDB
RTN4
Tbio
Novelty:  0.00080371
p_int:  0.99999989
p_ni:  1.1e-7
Score:  0.678
Data Source:  BioPlex,STRINGDB
RTN2
Tbio
Novelty:  0.05184418
p_int:  0.999954009
p_ni:  0.000045983
p_wrong:  8e-9
Score:  0.648
Data Source:  BioPlex,STRINGDB
PLSCR1
Tbio
Family:  Enzyme
Novelty:  0.01483138
p_int:  0.999943246
p_ni:  0.00004451
p_wrong:  0.000012243
Score:  0.579
Data Source:  BioPlex,STRINGDB
FAM210B
Tbio
Novelty:  0.19704434
p_int:  0.999627812
p_ni:  0.000371872
p_wrong:  3.16e-7
Score:  0.177
Data Source:  BioPlex,STRINGDB
METTL7A
Tbio
Family:  Enzyme
Novelty:  0.10143651
p_int:  0.998971395
p_ni:  0.000226738
p_wrong:  0.000801866
Score:  0.199
Data Source:  BioPlex,STRINGDB
FAM241A
Tdark
Novelty:  1.04041354
p_int:  0.998603427
p_ni:  0.001390092
p_wrong:  0.000006481
Data Source:  BioPlex
GYPB
Tbio
Novelty:  0.00442195
p_int:  0.997723453
p_ni:  0.002276547
Data Source:  BioPlex
SERPINE2
Tbio
Novelty:  0.00246375
p_int:  0.997065554
p_ni:  0.002709739
p_wrong:  0.000224707
Score:  0.177
Data Source:  BioPlex,STRINGDB
CYB5R3
Tbio
Family:  Enzyme
Novelty:  0.00774258
p_int:  0.995051704
p_ni:  0.004948288
p_wrong:  8e-9
Score:  0.291
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1
52.4
monocyte count
1
1
1
38.8
1
1
0
1.1
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1
52.4
monocyte count
1
38.8
0
1.1
28.1
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
reticulon 1
VGNC:3320
452945
Macaque
reticulon 1
619184
Mouse
MGI:1933947
104001
Rat
RGD:620986
116644
Dog
reticulon 1
VGNC:51680
474178
Species
Name
OMA
EggNOG
Inparanoid
Chimp
reticulon 1
Macaque
reticulon 1
Mouse
Rat
Dog
reticulon 1
Publication Statistics
PubMed Score 55.17
PubMed score by year
PubTator Score 24.94
PubTator score by year
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Related Publications
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PMID
Year
Title