Tbio RTN1 Reticulon-1

Protein Summary

Description

May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. This gene is considered to be a specific marker for neurological diseases and cancer, and is a potential molecular target for therapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011]

Uniprot Accession IDs

• Q16799
• Q16800
• Q16801
• Q5BKZ4
• Q9BQ59

Gene Name

• RTN1

Ensembl ID

• ENST00000267484
• ENSP00000267484
• ENSG00000139970
• ENST00000342503
• ENSP00000340716

Symbol

• NSP
• NSP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.98
PubMedID	0.94
kinase perturbation	0.91
hub protein	0.75
transcription factor perturbation	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.47   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 455   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.47   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 455   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0