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Tbio
RTKN
Rhotekin

Protein Summary
Description
Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures. This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233330
  • ENSP00000233330
  • ENSG00000114993
  • ENST00000272430
  • ENSP00000272430
  • ENST00000305557
  • ENSP00000305298

Symbol
  • RTKN1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
transcription factor
0.89
transcription factor binding site profile
0.79
kinase perturbation
0.71
cell type or tissue
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.97   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 222   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.97   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 222   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (77)
TAX1BP3
Tbio
Novelty:  0.01605171
p_int:  0.999999994
p_ni:  6e-9
Score:  0.982
Data Source:  BioPlex,Reactome,STRINGDB
RHOC
Tbio
Family:  Enzyme
Novelty:  0.00262213
p_int:  0.999882857
p_ni:  0.000022504
p_wrong:  0.000094639
Score:  0.983
Data Source:  BioPlex,Reactome,STRINGDB
NAA30
Tbio
Family:  Enzyme
Novelty:  0.04701961
p_int:  0.998388517
p_ni:  0.001604931
p_wrong:  0.000006552
Data Source:  BioPlex
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.995
Data Source:  Reactome,STRINGDB
LIN7B
Tbio
Novelty:  0.12689192
Score:  0.994
Data Source:  Reactome,STRINGDB
RHOB
Tbio
Family:  Enzyme
Novelty:  0.0019205
Score:  0.966
Data Source:  Reactome,STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.838
Data Source:  STRINGDB
GOPC
Tbio
Novelty:  0.01110168
Score:  0.721
Data Source:  STRINGDB
SEPT4
Tbio
Novelty:  0.0037115
Score:  0.715
Data Source:  STRINGDB
LIN7A
Tbio
Novelty:  0.0202389
Score:  0.71
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (110)
RHO GTPase Effectors (R-HSA-195258)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases Activate Rhotekin and Rhophilins
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
RHO GTPase Effectors
RHO GTPases Activate Rhotekin and Rhophilins
Signal Transduction
Signaling by Rho GTPases
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
1
1
64.9
platelet crit
1
1
1
59
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
64.9
platelet crit
1
59
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
rhotekin
VGNC:357
459334
Macaque
rhotekin
708722
Mouse
MGI:107371
20166
Rat
RGD:727874
297383
Dog
rhotekin
VGNC:45789
475788
Species
Name
OMA
EggNOG
Inparanoid
Chimp
rhotekin
Macaque
rhotekin
Mouse
Rat
Dog
rhotekin
Publication Statistics
PubMed Score 45.97
PubMed score by year
PubTator Score 12.74
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title