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Tbio
RTF1
RNA polymerase-associated protein RTF1 homolog

Protein Summary
Description
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389629
  • ENSP00000374280
  • ENSG00000137815

Symbol
  • KIAA0252
  • GTL7
  • KIAA0252
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.91
histone modification site profile
0.88
disease perturbation
0.83
virus perturbation
0.79
cell type or tissue
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.48   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.48   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (186)
FGF12
Tbio
Novelty:  0.02094849
p_int:  0.999999933
p_ni:  6.1e-8
p_wrong:  5e-9
Data Source:  BioPlex
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
p_int:  0.999999839
p_ni:  2.1e-8
p_wrong:  1.4e-7
Data Source:  BioPlex
PLEKHJ1
Tdark
Novelty:  1.44399298
p_int:  0.999999057
p_ni:  9.43e-7
Data Source:  BioPlex
DENND2D
Tbio
Novelty:  0.16496649
p_int:  0.999998859
p_ni:  0.000001141
Score:  0.214
Data Source:  BioPlex,STRINGDB
EPB41L3
Tbio
Novelty:  0.00915217
p_int:  0.999906884
p_ni:  0.00009311
p_wrong:  6e-9
Data Source:  BioPlex
ARRB2
Tbio
Novelty:  0.00148149
p_int:  0.99990018
p_ni:  0.00009982
Score:  0.659
Data Source:  BioPlex,STRINGDB
ARRB1
Tbio
Novelty:  0.00262758
p_int:  0.999715915
p_ni:  0.000267235
p_wrong:  0.00001685
Score:  0.821
Data Source:  BioPlex,STRINGDB
CDC73
Tbio
Novelty:  0.00362973
Score:  0.999
Data Source:  STRINGDB
SUPT16H
Tbio
Family:  Enzyme
Novelty:  0.01026868
Score:  0.999
Data Source:  STRINGDB
LEO1
Tbio
Family:  Enzyme
Novelty:  0.00851903
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
E3 ubiquitin ligases ubiquitinate target proteins (R-HSA-8866654)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
E3 ubiquitin ligases ubiquitinate target proteins
Reactome
Formation of RNA Pol II elongation complex
Reactome
Gene expression (Transcription)
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
E3 ubiquitin ligases ubiquitinate target proteins
Formation of RNA Pol II elongation complex
Gene expression (Transcription)
Metabolism of proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
2
2
2
80.6
lymphocyte percentage of leukocytes
2
2
2
74.6
childhood onset asthma
1
1
0
1.1
70.2
3
2
2
1.1
66.8
3
2
0
1
66
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
2
80.6
lymphocyte percentage of leukocytes
2
74.6
childhood onset asthma
0
1.1
70.2
2
1.1
66.8
0
1
66
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RTF1 homolog, Paf1/RNA polymerase II complex component
VGNC:6597
740192
Macaque
RTF1 homolog, Paf1/RNA polymerase II complex component
706200
Mouse
MGI:1309480
76246
Dog
RTF1 homolog, Paf1/RNA polymerase II complex component
VGNC:45787
487506
Horse
RTF1 homolog, Paf1/RNA polymerase II complex component
VGNC:22610
100071156
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RTF1 homolog, Paf1/RNA polymerase II complex component
Macaque
RTF1 homolog, Paf1/RNA polymerase II complex component
Mouse
Dog
RTF1 homolog, Paf1/RNA polymerase II complex component
Horse
RTF1 homolog, Paf1/RNA polymerase II complex component
Publication Statistics
PubMed Score 42.48
PubMed score by year
PubTator Score 6.22
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title