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Tbio
RTEL1
Regulator of telomere elongation helicase 1

Protein Summary
Description
ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere. This gene encodes a DNA helicase which functions in the stability, protection and elongation of telomeres and interacts with proteins in the shelterin complex known to protect telomeres during DNA replication. Mutations in this gene have been associated with dyskeratosis congenita and Hoyerall-Hreidarsson syndrome. Read-through transcription ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318100
  • ENSP00000322287
  • ENSG00000258366
  • ENST00000360203
  • ENSP00000353332
  • ENST00000370018
  • ENSP00000359035
  • ENST00000482936
  • ENSP00000457868
  • ENST00000508582
  • ENSP00000424307

Symbol
  • C20orf41
  • KIAA1088
  • NHL
  • NHL
  • RTEL
  • DKCA4
  • DKCB5
  • PFBMFT3
  • C20orf41
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.85
transcription factor binding site profile
0.83
phenotype
0.73
tissue sample
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.6   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.6   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0